The article is devoted to the importance of means of hormonal contraception as a method alternative to abortion, that can aid in preserving the reproductive health of women. The advantages, the main effects and the effectiveness of hormonal contraception and in particular drugs containing chlormadinone acetate (HMA), in patients with irregular menstrual symptoms and hyperandrogenism are discussed as well. The data comes from the study, which allows to regard HMA-containing COCs not only as an effective contraceptive agent with a low percentage of side effects, but a compound having a non-contraceptive effects in the form of a therapeutic effect on acne vulgaris, seborrhea, and other manifestations of hyperandrogenism.
Key words: hormonal contraception, hyperandrogenism, treatment of acne and seborrhea, chlormadinone acetate.
About the Author
V.N.Prilepskaya, E.A.Mezhevitinovа, A.A.Kuzemin
Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
1. Reproduktivnoe zdorov'e. Sbornik statisticheskikh dannykh Minzdrava Rossii, 2013; s. 10–1. [in Russian] 2. Al'banova V.I., Zabnenkova O.V. Ugri. Uchebnoe posobie dlia vrachei. M., 2014. [in Russian] 3. Jemes 2002. The Cochrane Library. Review 2012. 4. Polli 2001. The Cochrane Library. Review 2012. 5. Boyle J et al. Polycystic ovary syndrome An update. 2012; 41 (10): 752–6. 6. Seaman 2003. The Cochrane Library. Review 2012. 7. O’Connell 2008. The Cochrane Library, 2009. Issue 3. 8. Krattenmacher R. Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception 2000; 62: 29–38. 9. Georg AK. Schramma, Guido Schrahb. The efficacy and safety of an oral contraceptive containing chlormadinone acetate: results of a pooled analysis of noninterventional trials in adult and adolescent women. Contraception 2003; 67 (4): 305–12. 10. Caruso S, Rugolo S, Agnello C et al. Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. J Sex Med 2009; 6 (12): 3376–84. 11. Demograficheskii poniatiinyi slovar'. Naselenie Rossii. 20-i ezhegodnyi demograficheskii doklad. Pod red. A.G.Vishnevskogo. M., 2012. [in Russian] 12. Blak M., Makai M. i dr. Kozhnye bolezni v akushersko-ginekologicheskoi praktike. Pod red. V.N.Prilepskoi, E.V.Lipovoi. 2008. [in Russian] 13. Arowojolu AO, Gallo MF, Lopez LM, Grimes DA. Combined oral contraceptive pills for treatment of acne. The Cochrane Library, 2012. 14. Hadji P, Biskup J, Boekhoff J et al. Evaluation of efficacy, safety and effects on symptoms of androgenization of a generic oral contraceptive containing chlormadinone acetate 2 mg/ethinylestradiol 0,03 mg. Contraception 2012; 86 (4): 359–65. 15. Prilepskaya VN, Serov VN, Zharov EV et al. Golubev, Effects of aphasicoral contraceptive сontaining desogestre lonfacial seborrhea and acne. Contraception 2003; 68: 239–45.