Objective. To examine a course of pregnancy, perinatal outcomes in pregnant women vaccinated against influenza and pregnant women who have had an acute respiratory infection (ARI).
Material and methods. A comparative study of 108 pregnant women, vaccinated against influenza with vaccines Grippol® plus and Agrippal S1, and 93 unvaccinated; as well as study of 185 pregnant women (50 of whom had experienced ARI during pregnancy, 135 – not) during the 2009–2010 influenza pandemic. Were applied clinical, instrumental, immunological, statistical methods.
Results. It has been proven that immunization with inactivated subunit vaccines in the second and third trimester does not impact on the clinical course of pregnancy or the intrauterine growth of fetus. Respiratory infections result in increased frequency of obstetrics pathologies (subcompensated placental insufficiency 49.6%, chronic fetal hypoxia 49.6%, gestosis 35.5% and other). Adaptation in the early neonatal period among infants born to the vaccinated women is comparable to that of infants from the placebo group.
The infants born to the women having a history of ARI were 3 times or more frequent to have impaired adaptation, grade I cerebral ischemia, neonatal hyperbilirubinemia.
Conclusion. Vaccination of pregnant women in the II and III trimester of gestation with immunoadjuvant and unadjuvanted subunit influenza vaccine does not affect the course of pregnancy and the early neonatal period.
Key words: influenza vaccine, vaccination during pregnancy, birth outcomes in vaccinated, neonatal period.
About the Author
M.P.Kostinov1, A.P.Cherdantsev2, S.S.Semenova3, D.A.Tarbaeva4, A.A.Savisko5, O.F.Serova6,7, S.A.Iozefson4, N.K.Akhmatova1, T.A.Kostinova1, D.A.Praulova8
1I.I.Mechnikov Research Institute of Vaccines and Sera. 105064, Russian Federation, Moscow, Malyi Kazennyi per., d. 5a;
2Ulyanovsk State University. 432700, Russian Federation, Ulyanovsk, pl. 100-letiia so dnia rozhdeniia V.I.Lenina, d. 4;
3Сity Clinical Hospital №45 of the Department of Health of the Russian Federation. 125171, Russian Federation, Moscow, 1-ia Radiatorskaia, d. 5;
4Chita State Medical Academy 672090, Russian Federation, Chita, ul. Gor'kogo, d. 39a;
5Rostov State Medical University. 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29;
6Moscow Regional Perinatal Center. 143900, Russian Federation, Balashikha, sh. Entuziastov, d. 12;
7A.I.Burnazyan Federal Medical Biophysical Center. 123098, Russian Federation, Moscow, ul. Marshala Novikova, d. 23;
8Dmitrii Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Samory Mashela, d. 1
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