The paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing the ratio between the standardized rates of accumulation of the lumbar vertebrae and femoral neck, and increase bone mineral density (BMD) of the lumbar vertebrae (L2–L4) using HRT. Determined inverse relationship between the initial level of the BMD and its growth against the backdrop of 12 months of use of HRT drugs. Established predictive model will allow a reasonably prescribe HRT that will enhance the efficiency of correction postmenopausal osteoporotic changes and reduce the side effects associated with the use of this group of drugs.
Key words: postmenopausal osteoporosis, bone mineral density, hormone replacement therapy, prognosis.
About the Author
I.S.Zakharov, G.I.Kolpinskiy, G.A.Ushakova
Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation.
650056, Russian Federation, Kemerovo, ul. Voroshilova, d. 22a
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