During pregnancy and breastfeeding, the needs of the woman's body increase. Food substances entering the body are used both for feeding the mother's body and for building the organs (structures) of the fetus and its life support. Deficit states contribute to the development of various obstetric complications, pathological course of pregnancy and childbirth, adversely affect the formation of the placenta, the transmission through it of micronutrients from mother to child, increase the risk of deficiency in the child, violations of early neonatal adaptation and the formation of abnormalities in the health of children at the stage of postnatal ontogenesis. Daily vitamin D supplementation throughout pregnancy has a preventive effect and may reduce the risk of preeclampsia, endothelial dysfunction, gestational diabetes, preterm birth, neonatal hypocalcemia.
Key words: vitamin D, prevention, obstetric and neonatal complications, endothelial dysfunction, deficit states.
For citation: Lomova N.A., Karapetyan T.E., Dolgopolova E.L., Malbakhova E.T. Vitamin D deficiency: a modern approach to pathogenesis and therapy. Gynecology. 2018; 20 (5): 68–70. DOI: 10.26442/2079-5696_2018.5.68-70
About the Author
N.A.Lomova*1, T.E.Karapetyan1, E.L.Dolgopolova1, E.T.Malbakhova2
1V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
2Clinic "Mother and child" Savelovskaya. 127015, Russian Federation, Moscow, ul. Butyrskaia, d. 46
1. Scientific Advisory Committee on Nutrition. Influence of maternal, fetal and child nutrition on the development of chronic disease in later life. London: The Stationery Office, 2011.
2. Royal College of Obstetricians and Gynecologists. Nutrition in pregnancy. Scientific Advisory Committee Opinion Paper 18. September 2010. Available from: http://www.rcog.org.uk/
3. Scientific Advisory Committee on Nutrition: Vitamin D and Health. London: The Stationary Office, 2016.
4. Arundel P, Ahmed SF, Allgrove J et al. British Paediatric and Adolescent Bone Group’s position statement on vitamin D deficiency. Br Med
J 2012; 345: e8182.
5. Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr 2012; 36 (Suppl. 1): 9S–19S. DOI: 10.1177/0148607111430189
6. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91 (5): 1255–60. DOI: 10.3945/ajcn.2009.29094
7. Pulver AE, McGrath JA, Liang KY et al. An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 124B (1): 6–9.
8. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: Cd001059.
9. Al Mheid I, Patel R, Murrow J et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 18692.
10. Schulz EV, Cruze L, Wei W et al. Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. J Steroid Biochem Mol Biol 2017; 173: 273–9.
11. Bodnar LM, Catov JM, Simhan HN et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517–22.
12. Asemi Z, Hashemi T, Karamali M et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98: 1425–32.
13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27–32.
14. Lacroix M, Battista MC, Doyon M et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol 2014.
15. Scholl TO, Chen X, Stein P. Maternal vitamin D status and delivery by cesarean. Nutrients 2012; 4: 319–30.
16. Zhou J, Su L, Liu M et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
17. Harvey N, Holroyd C, Ntani G et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18: 1–190.
18. De-Regil LM, Palacios C, Lombardo LK et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016.
19. Roth DE, Leung M, Mesfin E et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. Br Med J 2017; 359: j5237.
20. Grant CC, Stewart AW, Scragg R et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2013.
21. Marya RK, Rathee S, Lata V et al. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155–61.
22. Hashemipour S, Lalooha F, Zahir Mirdamadi S et al. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr 2013; 110: 1611–6.