Effect of four-week semaglutide therapy and its combination with intranasal insulin on thyroid and gonadal status in male rats with type 2 diabetes

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Дәйексөз келтіру

Толық мәтін

Аннотация

Currently, semaglutide, glucagon-like peptide-1 (GLP-1) receptor agonist, is widely used to treat type 2 diabetes mellitus (T2DM) and obesity, but its effect on the endocrine system functions disrupted in the diseases remains poorly understood. There are no data on the possible enhancement of the effect of semaglutide in the presence of intranasal administered insulin (IAI). The aim of the work was to study the effect of a four-week treatment of adult male rats with T2DM with semaglutide (50 μg/kg/day, subcutaneously) and its combination with IAI (2 IU/rat/day) on the hormonal parameters of the thyroid and gonadal systems. T2DM was induced by a high-fat diet and a low-dose streptozotocin. Along with glucose homeostasis parameters and insulin levels, the levels of thyroid hormones (fT4, tT4, fT3, and tT3), thyroid-stimulating hormone (TSH), testosterone and luteinizing hormone (LH) were assessed in the blood of animals. In rats with T2DM, semaglutide was shown to reduce body weight and fat mass, improve glucose tolerance and insulin sensitivity, and restore triiodothyronine levels and peripheral thyroid hormone conversion. Combined use with IAI enhanced the stimulating effects of semaglutide on the decreased levels of thyroid hormones in T2DM and normalized the increased level of TSH in T2DM and the sensitivity of the thyroid gland to TSH, assessed by the integral thyroid index. Both monotherapy with semaglutide and its combination with IAI partially restored testosterone levels decreased in T2DM, preventing androgen deficiency. Thus, semaglutide and its combination with IAI can be used to correct endocrine disorders in T2DM, which is important for clinical endocrinology and reproductive medicine.

Авторлар туралы

K. Derkach

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences

Email: derkatch_k@list.ru
St. Petersburg, Russia

I. Zorina

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences

St. Petersburg, Russia

I. Fedorchuk

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences

St. Petersburg, Russia

A. Shpakov

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences; Faculty of Medicine, St. Petersburg State University

St. Petersburg, Russia; St. Petersburg, Russia

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