The effect of chronic stress and TAAR1 knockout on behavior characteristics of mice in tests assessing depressive-like behavior

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The aim of the study was to study the functional role of the TAAR1 receptor in the formation of the behavioral component of the stress response. The behavior of TAAR1–KO knockout mice and wild type (WT) mice was studied in tests reflecting a depressive-like state before and after the end of chronic stress (predator stress model), as well as delayed behavioral changes after 6 weeks. In the "hanging by the tail" test and the forced swimming Porsolt test, there were no differences between the TAAR1–KO and WT groups in terms of depressive-like behavior both during normal and after chronic stress exposure. However, TAAR1–KO mice, when placed in a stressful situation at the beginning of testing, demonstrate motor hyperactivity, which leads to a sharp increase in the latency periods of the first immobilization in both tests. Knockout of the TAAR1 receptor does not affect the signs of depressive-like behavior; however, it leads to a characteristic increase in the level of motor activity.

Sobre autores

E. Vinogradova

Saint Petersburg State University

Email: e.vinogradova@spbu.ru
St. Petersburg, Russia

A. Aleksandrov

Saint Petersburg State University

St. Petersburg, Russia

D. Belyakov

Saint Petersburg State University

St. Petersburg, Russia

E. Dmitrieva

Saint Petersburg State University

St. Petersburg, Russia

L. Stankevich

Saint Petersburg State University

St. Petersburg, Russia

A. Aleksandrov

Saint Petersburg State University

St. Petersburg, Russia

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