Старение клеток скелетных мышц: возраст, саркопения, терапия

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Прогрессирующее возрастное снижение массы, силы и функции скелетных мышц приводит к потере и атрофии мышечных волокон и сопутствующему замещению их жировой и фиброзной тканью, саркопении. Мышцы подвержены множественным формам молекулярных и клеточных повреждений, включая нарушение регенеративной способности, оборота белков, митохондриальную дисфункцию и клеточное старение, которое проявляется остановкой клеточного цикла. С возрастом такие клетки накапливаются и приобретают отличительные свойства, характеризующиеся изменениями хроматина и появлением специфического секреторного, связанного со старением фенотипа (SAS-фенотип), который оказывает локальное и/или системное негативное влияние на ткани организма. Цель настоящего обзора – представить ландшафт признаков старения клеток скелетных мышц, основанный на данных доказательства их роли в возрастном изменении массы, силы, функции мышц и клинических последствий данного явления, а также продемонстрировать ключевые направления в разработке новых методов сенесцентной терапии саркопении. Критерии включения: рандомизированные или нерандомизированные контролируемые исследования, изучающие роль старения клеток в возрастзависимом изменении и патофизиологии скелетных мышц. Поиск данных осуществляли в электронных научных базах Google Scholar, Medline, PubMed, Scopus, Web of Science и Cochrane Library по ключевым словам и их сочетаниям, используя программу AMSTAR 2. Отбор публикаций (из 430 включено 82) производили случайным образом, после чего независимо авторами давалась оценка их методологического качества. Доказана решающая роль клеточного старения при формировании SAS-фенотипа в возрастной патофизиологии скелетных мышц. Эти явления изменяют гомеостаз мышечной ткани и способствуют возникновению и прогрессированию саркопении. Воздействие на стареющие клетки и их секреторные профили может способствовать разработке комплексных стратегий, включая использование сенолитиков и сеноморфов, для улучшения качества жизни стареющей популяции населения. С другой стороны, на настоящий момент недостаточно данных об уязвимости к старению терминально-дифференцированных волокон скелетных мышц и резидентных мононуклеарных клеток интерстициального микроокружения. Приводятся различные мнения о вкладе этого явления в начало и прогрессирование возрастной потери массы и дисфункции скелетных мышц, а также инициации саркопении. Научные достижения в данной области позволят определить новые терапевтические подходы для оптимизации здоровья мышц в пожилом возрасте.

Об авторах

Н. Г. Плехова

Тихоокеанский государственный медицинский университет Минздрава России

Email: pl_nat@hotmail.com
Владивосток, Россия

П. А. Новикова

Тихоокеанский государственный медицинский университет Минздрава России

Владивосток, Россия

А. Н. Воронова

Тихоокеанский государственный медицинский университет Минздрава России

Владивосток, Россия

Д. В. Королев

Тихоокеанский государственный медицинский университет Минздрава России

Владивосток, Россия

В. Б. Шуматов

Тихоокеанский государственный медицинский университет Минздрава России

Владивосток, Россия

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