GynecologyGynecology2079-56962079-5831Consilium Medicum10048510.26442/20795696.2022.6.201749Review ArticleEstetrol: a new estrogen component in combined oral contraceptives: A reviewHamadyanovaAida U.<p>Cand. Sci. (Med.), Bashkir State Medical University</p>sagidullin12@bk.ruhttps://orcid.org/0000-0001-6197-195XTuhtaboevAfzal H.<p>Student, Bashkir State Medical University</p>tuhtaboevafzal@mail.ruhttps://orcid.org/0000-0002-3705-5692ShafievaVenera A.<p>Student, Bashkir State Medical University</p>shafiyeva1999@inbox.ruhttps://orcid.org/0000-0001-9563-8856KolodyazhnayaElena A.<p>Resident, Bashkir State Medical University</p>elena_l_a@list.ruhttps://orcid.org/0000-0001-5133-7293MansurovaJulia R.<p>Resident, Bashkir State Medical University</p>yuliyayull@yandex.ruhttps://orcid.org/0000-0002-4503-8200MuratovaAliya A.<p>Student, Bashkir State Medical University</p>muratova99@bk.ruhttps://orcid.org/0000-0003-0875-0693AndreevaArina A.<p>Student, Bashkir State Medical University</p>arina.andreeeva53@gmail.comhttps://orcid.org/0000-0001-5572-1663MuzafarovaJulia A.<p>Student, Bashkir State Medical University</p>muzjulya@gmail.comhttps://orcid.org/0000-0001-9855-3022Bashkir State Medical University211220222464594641002202215062022Copyright © 2022, Consilium Medicum2022<p>Estetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta. Its concentration in maternal human plasma increases during pregnancy, reaching a maximum by the end of pregnancy (1 ng/mL). The pharmacological properties of E4 make it a promising agent for hormonal therapy and contraception. To date, phase II and III studies have shown promising results with the combination of 15 mg of E4 and 3 mg of drospirenone: this combined oral contraceptive has shown a good effect with a neutral metabolic effect. However, evidence is scarce about the effect of the new combination on the breast and bone tissue. 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