GynecologyGynecology2079-56962079-5831Consilium Medicum10957710.26442/20795696.2022.4.201824Review ArticleProspects of exogenous inositols in maintaining of skin, hair and nails condition: A reviewGromovaOlga A.<p>D. Sci. (Med.), Prof.</p>unesco.gromova@gmail.comhttps://orcid.org/0000-0002-7663-710XTorshinIvan Yu.<p>Cand. Sci. (Chem.), Cand. Sci. (Phys.-Math.)</p>tiy135@ccas.ruhttps://orcid.org/0000-0002-2659-7998TetruashviliNana K.<p>D. Sci. (Med.)</p>n_tetruashvili@oparina4.ruhttps://orcid.org/0000-0002-9201-2281Federal Research Center “Informatics and Management”Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology290920222442612700108202231082022Copyright © 2022, Consilium Medicum2022<p>Myoinositol (MI) and D-chiroinositol (DCI), used in the therapy of menstrual disorders, polycystic ovarian syndrome (PCOS), hirsutism, acne, gestational diabetes, and other diseases, are required for intracellular signal transduction from insulin and other hormone receptors. Clinical practice shows that, for instance, MI and DCI in the treatment of PCOS improve the condition of skin, hair, and nails. These effects of MI and DCI are related to the normalization of insulin signaling and support of differentiation and growth of various skin cell types (keratinocytes, fibroblasts, epitheliocytes, etc.). The effects of MI and DCI on the skin and its appendages, including in wound healing, can be enhanced by manganese, which provides an antioxidant effect and improves the connective tissue matrix of the skin, and folic acid, which is involved in amino acid metabolism, proliferation, and differentiation of dividing cells.</p>myoinositolD-chiroinositolmanganeseskinDikirogenмиоинозитолD-хироинозитолмарганецфолиевая кислотакожаДикироген[Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. 2-е издание. М.: ГЭОТАР-Медиа, 2022, 832 c. [Gromova OA, Torshin IYu. Micronutrients and reproductive health. Management. 2nd edition. Moscow: GEOTAR-Media, 2022, 832 p. (in Russian)].][Лиманова О.А., Громова О.А., Торшин И.Ю., и др. Систематический анализ молекулярно-физиологических эффектов мио-инозитола: данные молекулярной биологии, экспериментальной и клинической медицины. Эффективная фармакотерапия. 2013;28:32-41 [Limanova OA, Gromova OA, Torshin IYu, et al. 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