GynecologyGynecology2079-56962079-5831Consilium Medicum11500010.26442/20795696.2022.5.201928Research ArticleComparative evaluation of functional constipation prevention methods in pregnant womenRybakovaTatiana N.<p>Assistant of Professor</p>rybakova_1992@bk.ruhttps://orcid.org/0000-0002-3868-3746NazarovaLyudmila V.<p>Assistant of Professor</p>nazaro-mila@rambler.ruhttps://orcid.org/0000-0001-5713-9829KovalenkoMaxim S.<p>and. Sci. (Med.), Assoc. Prof.</p>mskovalenko@yandex.ruhttps://orcid.org/0000-0002-2275-5426TuzlukovIgor I.<p>Cand. Sci. (Med.)</p>doktorti357@gmail.comhttps://orcid.org/0000-0002-6406-7226Pavlov Ryazan Medical University301120222453693733011202230112022Copyright © 2022, Consilium Medicum2022<p><strong>Aim. </strong>To perform a comparative evaluation of different methods for preventing functional constipation in pregnant women.</p>
<p><strong>Materials and methods. </strong>The study included 150 pregnant women aged 18 to 42 years, 22 to 36 weeks of gestation, with functional constipation. Group 1 included 50 patients who received dietary fiber OptiFibre in addition to diet therapy; group 2 included 50 patients who received diet therapy in combination with lactulose; group 3, the control group, included 50 pregnant women who received corrective diet therapy only. The outcomes were evaluated on day 14 of observation.</p>
<p><strong>Results. </strong>A diet only was not sufficiently effective in normalizing stools in pregnant women with a gestational age of 2236 weeks. By day 14, stool frequency was restored in groups 1 and 2 patients. However, during lactulose use, gastrointestinal discomfort persisted more frequently; not all patients reported normal stools at the medium recommended dose, which required an increase of the dose. However, there were episodes of loose stool, which required discontinuation of the medicine. The best results were achieved with the combination of diet and partially hydrolyzed OptiFibre dietary fibers, both in terms of restoration of stool regularity, relief of associated gastrointestinal symptoms, and tolerance of the dietary fibers.</p>
<p><strong>Conclusion. </strong>Soluble dietary fiber OptiFibre, combined with diet therapy, restores regular stools and resolves constipation in pregnant women. It is well tolerated and safe to use in obstetric practice. The findings suggest using OptiFibre for constipation in pregnant women.</p>functional constipationstool disorderspregnancydietary fiberOptiFibrelactuloseфункциональный запорнарушения стулабеременностьпищевые волокнаОптиФайберлактулоза[Черемушкин С.В., Кучерявый Ю.А. Принципы лечения хронического запора. Медицинский совет. 2012;9:52-7 [Cheremushkin SV, Kucheriavyi IuA. Printsipy lecheniia khronicheskogo zapora. Meditsinskii sovet. 2012;9:52-7 (in Russian)].][Бурков С.Г. Запоры беременных: взгляд на проблему. Приложение РМЖ «Болезни органов пищеварения». 2006;1:28. Режим доступа: https://www.rmj.ru/articles/bolezni_organov_pishchevareniya/Zapory_beremennyh_vzglyad_na_problemu/. Ссылка активна на 10.10.2022 [Burkov SG. Constipation of pregnant women: a look at the problem. Appendix breast cancer “Diseases of the digestive system”. 2006;1:28. Available at: https://www.rmj.ru/articles/bolezni_organov_pishchevareniya/Zapory_beremennyh_vzglyad_na_problemu/ Accessed: 10.10.2022 (in Russian)].][Бурков С.Г. Запоры беременных: современный взгляд на проблему. Экспериментальная и клиническая гастроэнтерология. 2017;144(8):97-100 [Burkov SG. Constipation in pregnant women: a modern view on the problem. Eksperimental’naya i klinicheskaya gastroenterologiya. 2017;144(8):97-100 (in Russian)].][Лебедев В.А., Пашков В.М., Клиндухов ИА. Запоры у беременных: пути решения проблемы. Трудный пациент. 2012;8-9(10):6-9 [Lebedev VA, Pashkov VM, Klindukhov IA. Constipation in pregnancy: the ways to solve the problem. Trudnyi patsient. 2012;8-9(10):6-9 (in Russian)].][Рыкова С.М. Применение растительных препаратов при лечении запора. Трудный пациент. 2018;6(16):26-33 [Rykova SM. The Use of Herbal Remedies in Treatment of Constipation. Trudnyi patsient. 2018;6(16):26-33 (in Russian)].][Парфенов А.И. Современная терапия хронических запоров. Медицинский совет. 2013;1-2:98-103 [Parfyonov AI. Modern management of chronic constipation. Meditsinskiy sovet. 2013;1-2:98-100 (in Russian)].][Соколова М.Ю. Заболевания внутренних органов у беременных. М.: МИА, 2011; с. 262-89 [Sokolova MIu. Zabolevaniia vnutrennikh organov u beremennykh. Moscow: MIA, 2011; p. 262-89 (in Russian)].][Соколова М.Ю. Запоры у беременных. Медицинский совет. 2013;8:28-31 [Sokolova MYu. Constipation in pregnant women. Meditsinskiy sovet. 2013;8:28-31 (in Russian)].][Антоненко О.М. Лечение и профилактика запоров у беременных. Медицинский совет. 2012;7:52-5 [Antonenko OM. Lechenie i profilaktika zaporov u beremennykh. Meditsinskii sovet. 2012;7:52-5 (in Russian)].][Акушерство: национальное руководство. Под ред. Г.М. Савельевой, Г.Т. Сухих, В.Н. Серова, В.Е. Радзинского. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2018. Серия «Национальные Руководства». Режим доступа: https://www.rosmedlib.ru/book/ISBN9785970449165.html. Ссылка активна на 10.10.2022 [Akusherstvo: natsional'noe rukovodstvo. Pod red. GM Savel'evoi, GT Sukhikh, VN Serova, VE Radzinskogo. 2-e izd., pererab. i dop. M.: GEOTAR-Media, 2018. Seriia "Natsional'nye Rukovodstva". Available at: https://www.rosmedlib.ru/book/ISBN9785970449165.html. Accessed: 10.10.2022 (in Russian)].][Guilera M, Balboa A, Mearin F. Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. Am J Gastroenterol. 2005;100:1174-84.]