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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">27627</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Etiologicheskaya rol' virusa papillomy cheloveka v razvitii raka sheyki matki: geneticheskie i patogeneticheskie mekhanizmy, vozmozhnosti terapii i profilaktiki</article-title><trans-title-group xml:lang="ru"><trans-title>Этиологическая роль вируса папилломы человека в развитии рака шейки матки: генетические и патогенетические механизмы, возможности терапии и профилактики</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kiselev</surname><given-names>V I</given-names></name><name xml:lang="ru"><surname>Киселев</surname><given-names>В И</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт молекулярной медицины</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ashrafyan</surname><given-names>L A</given-names></name><name xml:lang="ru"><surname>Ашрафян</surname><given-names>Л А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Budarina</surname><given-names>S O</given-names></name><name xml:lang="ru"><surname>Бударина</surname><given-names>С О</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kiselev</surname><given-names>O I</given-names></name><name xml:lang="ru"><surname>Киселев</surname><given-names>О И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pal'tsev</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Пальцев</surname><given-names>М А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kulakov</surname><given-names>V I</given-names></name><name xml:lang="ru"><surname>Кулаков</surname><given-names>В И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prilepskaya</surname><given-names>V N</given-names></name><name xml:lang="ru"><surname>Прилепская</surname><given-names>В Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Московская медицинская академия им. И.М.Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Научный центр рентгенорадиологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Научный центр акушерства, гинекологии и перинатологии РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2004-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2004</year></pub-date><volume>6</volume><issue>4</issue><issue-title xml:lang="en">VOL 6, NO4 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 6, №4 (2004)</issue-title><fpage>174</fpage><lpage>180</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/27627">https://gynecology.orscience.ru/2079-5831/article/view/27627</self-uri><abstract xml:lang="ru"><p>В связи с появлением вирусной концепции цервикального канцерогенеза принципиально изменились и подходы к лечению диспластических процессов шейки матки. В настоящее время хирургические методы стали играть второстепенную роль, а на первое место вышла этиопатогенетическая терапия. Это обусловлено тем, что процент рецидивов после использования деструктивных методов достаточно высок. Причина заключается в том, что в случае хирургического лечения иссекается только видимый патологический очаг, а не этиологический фактор. Оставшийся в тканях ВПЧ, являясь сильнейшим канцерогеном, вновь провоцирует развитие неопластических процессов в цервикальном эпителии путем интеграции в клетки и выработки онкобелков. Поэтому при наблюдении за женщинами, перенесшими хирургическое лечение (включая криотерапию и лазеровапоризацию) по поводу диспластических процессов шейки матки, целесообразно определять концентрацию онкобелка Е7. Наличие Е7 должно являться показанием к проведению этиопатогенетической терапии.</p></abstract><kwd-group xml:lang="ru"><kwd>вирус папилломы человека</kwd><kwd>рак шейки матки</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Киселев В.И., Киселев О.И. Вирусы папилломы человека в развитии рака шейки матки. Спб.–М.: Роза мира, 2003.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Mc Cance D.J. Human papillomavirus (HPV) infection in the aetiology of cervical cancer. Cancer Sury 19884 7: 499–506.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bedell M.A, Jones K.H, Laimins L.A. The E6-E7 region of hu man papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells. J Virol 1987; 61: 3635–40.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Reeves W.G, Rawls W.E, Brinton L.A. Epidemiology of genital papillomavirus and cervical cancer. 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