GynecologyGynecology2079-56962079-5831Consilium Medicum27735Research ArticleVoprosy patogeneza i profilaktiki katastroficheskogo antifosfolipidnogo sindroma v akusherskoy praktikeMakatsariyaA D-BitsadzeV O-Akin'shinaS V-150620068371509042020Copyright © 2006, Consilium Medicum2006антифосфолипидный синдромтромбозантикоагулянтная терапия[Cervera R, Font J, Gomez-Puerta J.A, Espinosa G et al.; Catastrophic Antiphospholipid Syndrome Registry Project Group. Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome. Ann Rheum Dis. 2005;64:1205-9.][Asherson R.A. The catastrophic antiphospholipid syndrome. J Rheumatol 1992;19:508-12.][Asherson R.A. Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome. Immunobiology 2005;210:727-33.][Asherson R.A, Cervera R, de Groot P.G; Catastrophic Antiphospholipid Syndrome Registry Project Group. Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 2003;12:530-4.][Wiedermann F.J, Mayr A, Schobersberger W. Acute respiratory failure associated with catastrophic antiphospholipid syndrome. J Intern Med 2000;247:723-30.][Asherson R.A. Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome. Immunobiology. 2005;210:727-33.][Баркаган З.С., Момот А.П., Сердюк Г.В. Основы диагностики и терапии антифосфолипидного синдрома. М.: Ньюдиамед. 2003.][Насонов Е. Л. Антифосфолипидный синдром. М.: Литтера. 2004.][Vora S.K, Asherson R.A, Erkan D. Catastrophic antiphospholipid syndrome. J Intensive Care Med. 2006; 21:144-59.][Asherson R.A, Shoenfeld Y. The role of infection in the pathogenesis of catastrophic antiphospholipid syndrome--molecular mimicry? J Rheumatol 2000;27:12-4.][Gharavi A.E, Pierangeli S.S, Harris E.N.New developments in viral peptides and APL induction. J Autoimmun. 2000;15:227-30.][Raschi E, Testoni C, Bosisio D.Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003;101:3495-500.][ten Cate H. Pathophysiology of disseminated intravascular coagulation in sepsis. Crit Care Med 2000;28:9-11][Asherson R.A, Espinosa G, Cervera R et al. Disseminated intravascular coagulation in catastrophic antiphospholipid syndrome: clinical and haematological characteristics of 23 patients. Ann Rheum Dis 2005;64:943-46.][Karmochkine M, Mazoyer E, Marcelli A et. al. High prevalence of antiphospholipid antibodies in disseminated intravascular coagulation. Thromb Haemost 1996;75:971.][de Groot P.G, Horbach D.A, Derksen R.H. Protein C and other cofactors involved in the binding of antiphospholipid antibodies: relation to the pathogenesis of thrombosis. Lupus 1996;5:488-93.][Lu C.S, Horizon A.A, Hwang K.K. Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 2005;52:4018-27.][Kitchens C.S. Thrombotic storm: when thrombosis begets thrombosis. Am J Med 1998;104:381-5.][Yasuda S, Atsumi T, Matsuura E. Significance of valine/leucine247 polymorphism of b2-glycoprotein I in antiphospholipid syndrome: increased reactivity of anti - b2-glycoprotein I autoantibodies to the valine247 b2-glycoprotein I variant.Arthritis Rheum 2005 Jan;52(1):212-8.][Katzav A, Evert T, Pick C.G. Induction of antiphospholipid syndrome in Factor V Leiden mice. Immunobiology 2005;209:10-11.][Brenner B, Hoffman R, Carp H et al.; LIVE-ENOX Investigators. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study. J Thromb Haemost 2005;3:227-29.][Lai S, Walker D.H, Elghetany M.T. Catastrophic antiphospholipid syndrome: a rare cause of disseminated microvascular thrombotic injury - a case report with pathological and molecular correlative studies. Pathol Int 2005;55:144-49.][Makatsariya A., Asherson R.A., Bitsadze V., Baimuradova S., Akinshina S. Catastrophic antiphospholipid (asherson's) syndrome and genetic thrombophilic disorders in obstetrics. Autoimmun. Rev. 2006. Article in press.][Lu C.S, Horizon A.A, Hwang K.K. Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 2005;52:4018-27.][Carmona F, Lazaro I, Reverter J.C. Impaired factor XIIa - dependent activation of fibrinolysis in treated antiphospholipid syndrome gestations developing late - pregnancy complications. Am J Obstet Gynecol 2006;194:457-65.][Le Thi Thuong D, Tieulie N. The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women. Ann Rheum Dis 2005;64:273-8.][Bashiri A, Burstein E, Mazor M. Cerebral palsy and fetal inflammatory response syndrome: a review. J Perinat Med 2006;34(1):5-12.][Makatsariya A., Bitsadze V., Baimuradova S., Khizroeva D. K., Akinshina S. Fetal thrombophilia and obstetrics complications. Pathophysiology of haemostasis and thrombosis. Proceeding and abstracts from the 19th International Congress on Thrombosis. Tel-Aviv, Israel, May 140-18, 2006:A10.][Asherson R.A. The catastrophic antiphospholipid syndrome (Asherson's syndrome). Monograph collected papers. 1992-2005.][Bernard G.R, Vincent J.L, Laterre P.F; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001. 344(10):699-709.][Erkan D, Leibowitz E, Berman J, Lockshin M.D.Perioperative medical management of antiphospholipid syndrome: hospital for special surgery experience, review of literature, and recommendations. J Rheumatol 2002; 29(4):843-9.]