GynecologyGynecology2079-56962079-5831Consilium Medicum27769Research ArticleGormonal'naya vnutrimatochnaya rilizing-sistema "Mirena"TagievaA V-AbakarovaP R-1508200684293309042020Copyright © 2006, Consilium Medicum2006контрацепциягормональное внутриматочное средство[Менопаузальный синдром (клиника, диагностика, профилактика и заместительная гормональная терапия). Под ред. В.И.Кулакова, Е.М.Вихляевой. М., 1996; 64.][Прилепская В.Н., Межевитинова Е.А., Тагиева А.В. Внутриматочная контрацепция: Руководство. М.: МедПресс, 2000; 325.][Ревазова Ф.С. Клинико - морфологические особенности внутриматочной контраепции: Автореф.. дис. канд. мед. наук. 2003; 26.][Тагиева А.В. Эффективность и приемлемость левоноргестрел - содержащего внутриматочного средства "Мирена" у женщин репродуктивного возраста: Автореф. дис.. канд. мед. наук. 2001; 26.][Andersson K, Rybo G. Levonorgestrel - releasing intrauterine device in the treatment of menorrhagia. Brit J Obstet Gynecol 1990; 97: 690-4.][Andersson K, Odlind V, Rybo G. Levonorgestrel - releasing and copperreleasing (Nova T) IUDs during five years of use: a randomisod comparative trial. Contraception 1994; 49 (1): 56-72.][Antoniou G, Kalogirou D, Karakitosos P et al. Transdermal estrogen with a levonorgestrel - releasing intrauterine device for ckunacteruc complaints versus estradiol - releasing vaginal ring with a vaginal progesterone suppository: clinical and endometrial responses. Maturitas 1997; 26 (2): 103-11.][Barbosa I, Bakos O, Olsson S et al. Ovarian function during use of levonorgestrel - releasing IUD. Contraception 1990; 42: 51-66.][Barrington J, Bowen-Simpkins P. The levonorgestrel intrauterine system in the management of menorrhagia. Brit J Obstet Gynaecol 1997; 104 (5): 614-6.][Barrington J.W, Leary A.O, Bowen-Sinpkins P. Management of refractory pre - menstrual syndrome using subcutaneous oestradiol implants and levonorgestrel intrauterine systems. J Obstet Gynecol 1997; 17 (4): 416-7.][Coleman M, Cowan L, Farquhar C. The levonorgestrel - releasing intrauterine device: a wider role than contraception. Aust. NZ Obstet Gynaecol 1997; 37 (2): 195-202.][Critchley H, Wang H, Kelly R et al. Progestin receptor isoforms and prostaglandin dehydrogenase in the endometrium of women using using a levonorgestrel - releasing intrauterine system. Hum Reprod 1998; 13 (5): 1210-710.][Crosignani P, Vercellini P, Mosconi P at al. Levonorgestrel - releasing intrauterine device versus Hysteroscopic endometrial resection in the treatment of dycfunctional uterine bleeding. Obstet Gynecol 1997; 90: 257-63.][Greendale G, Lee N, Arriola E. The menopause. Lancet 1999; 353 (9152): 571-80.][Gu Z, Zhu P, Luo H at al. Morphometric study on the endometrial activity of woment before and after one year with LNG-IUD in situ. Contraception 1995; 52: 57-61.][Fedele L et al. Use of the levonorgestrel - releasing intrauterine device in the treatment of rectovaginal endometriosis Fert. Steril 2001; 75: 485-8.][Hurk P, O'Brien S. Non - contraceptive use of the levonorgestrel - releasing intrauterine system. Obstet Gynaecol 1999; 1 (1): 13-9.][Irvine G, Campbell-Brawn M, Lumsden M at al. Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of ikiopathic menorrhagia. Brit J Obstet Gynaecol 1998; 105 (6): 592-8.][Jarvela I, Tekay A, Jouppila P. The effect of a levonorgestrel - releasing intrauterine system on uterine artery bloodflow, hormone contrations and ovarian cyst formation in fertile women. Hum Reprod 1998; 13 (12): 3379-83.][Johansson E. Future aspects of the levonorgestrel - releasing intrauterine system. Gynecoly Forum 1998; 3 (3): 311-32.][Klein N, Soules M. endocrine changes of the perimenopause. Clin Obstet Gynecol 1998; 41 (4): 912-20.][Kubba A. Contraception: a review. IJCP 1998; 52 (2): 102-5.][Lahteenmaki P. Health benefits of a levonorgestrel - releasint IUD (abbstract). 7th European congress of Gynaecology and Obstetric, 1992; 28 June - 1 July, Helsinki, Finland.][Lahteenmaki P, Bardin C, eloma K et al. Selection and performance of the levonorgestrel - releasing intrauterine system. Obstet Gynaecol Scand 1997; 164: 69-74.][Mandelin E, Koistinen H, Koistinen R et al. Levonorgestrel - releasing intrauterine device - wearing women express contraceptive glycodelin-A in endometrium during midcycle: another contraceptive mechanism. Hum Reprod 1997; 12 (12): 2671-5.][Nilsson C.S, Lahteenmaki P.L.A, Luukkainen T. Ovarian function in amenorrheic and menstruating users of a levonorgestrel - releasing intrauterine device. Fert Steril 1984; 41 (1): 52-55.][Ortiz M.E, Croxatto H. Mode of action of IUDs//intrauterine Pakarinen P, Lahteenmaki P, Rutanen e. The effect of intrauterine and oral levonorgestrel administration on serum contracentrations of sex hormone - binding globulin, insulin and insulin - like growth factor binding protein-1. Acta Obstet Gynaecol 1999; 78 (5): 423-8.][Pakarinen P, Toivonen J, Luukkainen T. Randomized comprasion of a levonorgestrel - and copper - releasing system immediately after abortion, with 5 years folow up. contraception 2003; 68: 31-4.][Pekonen F, Nyman R, Lahteenmaki P et al. Intrauterine progestin induces continuous insulin growth factor - binding protein-1 production on the human endometrium. J Clin rndocrinol Metab 1992; 75: 660-4.][Rutanen E. Endometrial response to intrauterine release of levonorgestrel. Gynaecology Forum 1998; 3 (3): 11-3.][Rybo G. Tretment of menorrhagia using intrauterine administration of levonorgestrel. Gynecology Forum 1998; 3 (3): 20-2.][Sivin I, Health during prolonged use of levonorgestrel 20 micrograms/d and the Copper TCu 380 Ag intrauterine contraceptive devices: a multicenter study. International committe for contraception research (ICCR). Fertil Steril 1994; 61: 70-7.][Stewart A et al. The effectiveness of the levoneorgestrel - releasing intrauterine system in menorrhagia: a systematic review. BJOG: an International Journal of Obstetrics & Gynecology 2001; 108: 74-86.][Sturridge F, Guillebaund J. Gynaecological aspects of the levoneorgestrel - releasing intrauterine system. Brit J Obstet Gynaecol 1997; 104 (3): 285-9.][Suhonen S, Alonen H, Lahteenmaki P. Sustained - release estradiol implants and levonorgestrel - releasing intrauterine device in hormone replacement therepy. Am J Obstet Gynaecol 1995; 172: 562-7.][Suhonen S, Holmstrom T, allonen H et al. Intrauterine and subdermal progestin administration in postmenopausal hormone replacement therapy. Fertil Steril 1995; 63: 336-42.][Suvisaari I, Lahteenmaki P. Detailed analysis of menstrial bleeding patterns after postmenstrial and postbortal insertion of cooper IUD or a levonorgestrel - releasing intrauterine system. Contraception 1996; 54: 4.][Toivonen J, Luukkainen T et al. Postabortal insertion of a levonorgestrel releasing IUD (Abstract). Gynecol Endocrinol 1995; FC 23.][Toivonen J, Luukkainen T, Allonen H. Protective effect of intrauterine release of levonorgestrel on pelvic infection: three years' comparative experience of levonorgestrel - and copper - releasing intrauterine devices. Obstet Gynecol 1991; 77 (2): 261-4.]