GynecologyGynecology2079-56962079-5831Consilium Medicum28040Research ArticleNekotorye osobennosti klinicheskoy farmakologii progestinov (Obzor literatury)BulychevaE S-SturovN V-15082009114222609042020Copyright © 2009, Consilium Medicum2009[Katzung B.G. Basic & Clinical Pharmacology, Tenth Edition. – The Mc Graw - Hill Companies, Inc., 2007.][Schindler A.E, Campagnoli C, Druckmann R et al. Classification and pharmacology of progestins. Maturitas 2003; 46 (Suppl. 1): S7–16.][Sitruk-Ware R. New progestagens for contraceptive use. Hum Reprod Update 2006; 12 (2): 169–78.][Juchem M, Pollow K, Elger W et al. Receptor binding of norgestimate – a new orally active synthetic progestational compound. Contraception 1993; 47: 283–94.][Лейкок Дж.Ф., Вайс П.Г. Основы эндокринологии: Пер. с англ. М.: Медицина, 2000.][Sitruk-Ware R. New progestogens: a review of their effects in perimenopausal and postmenopausal women. Drugs Aging 2004; 21 (13): 865–83.][Stanczyk F.Z, Roy S. Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids. Contraception 1990; 42: 67–96.][Fotherby K, Caldwell A.D.S. New progestogens in oral contraception. Contraception 1994; 49: 1–31.][Upton G.V, Corbin A. The relevance of the pharmacologic properties of a progestational agent to its clinical effects as a combination oral contraceptive. Yale J Biol Med 1989; 62: 445–57.][Teichmann A.T. Empfangnisverhutung: eine vergleichende Ubersicht aller Methoden, Risiken und Indikationen. Stuttgart, Germany: Georg Thieme Verlag, 1996; 23–31.][van der Vange N, Blankenstein M.A, Kloosterboer H.J et al. Effects of several low - dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone. Contraception 1990; 41: 345–52.][Stanczyk F.Z, Leyden J, Kempers S et al. The effect of an oral contraceptive containing 20 µg ethinyl estradiol and 100 mg levonorgestrel (EE 20/LNG 100) on ovarian, adrenal, and peripheral androgens. Gynecol Endocrinol 2000; 14 (suppl.): 137.][Reubinoff B.E, Grubstein A, Meirow D et al. Effects of low - dose estrogen oral contraceptives on weight, body composition, and fat distribution in young women. Fertil Steril 1995; 63: 516–21.][Gallo M.F, Lopez L.M, Grimes D.A et al. Combination contraceptives: effects on weight. Cochrane Database of Syst Rev 2006; 1: CD003987.][Lello S, Vittori G, Paoletti A.M et al. Effects on body weight and body composition of a low - dose oral estro progestin containing ethinyl estradiol 20 microg plus levonorgestrel 100 microg. Gynecol Endocrinol 2007; 23 (11): 632–7.][Nessa A, Latif S.A, Uddin M.M. Glycemic status in women using combined oral contraceptive pill. Mymensingh Med J 2005; 14 (2): 165–8.][Сперофф Л., Дарни Ф.Д. Клиническое руководство по контрацепции. Пер. с англ. Под ред. В.Н.Прилепской. М.: Бином, 2009.][Sarfati J, de Vernejoul M.C. Impact of combined and progestogen - only contraceptives on bone mineral density. Joint Bone Spine 2009; 76 (2): 134–8.][Cromer B.A, Bonny A.E, Stager M et al. Bone mineral density in adolescent females using injectable or oral contraceptives: a 24-month prospective study. Fertil Steril 2008; 90 (6): 2060–7.][Warming L, Ravn P, Christiansen C. Levonorgestrel and 17beta - estradiol given transdermally for the prevention of postmenopausal osteoporosis. Maturitas 2005; 50 (2): 78–85.][Rapkin A.J, Morgan M, Sogliano C et al. Decreased neuroactive steroids induced by combined oral contraceptive pills are not associated with mood changes. Fertil Steril 2006; 85 (5): 1371–8.][Bancroft J, Sartorius N. The effects of oral contraceptives on well - being and sexuality. Oxf Rev Reprod Biol 1990; 12: 57–92.][Higgins J.A, Hoffman S, Graham C.A et al. Relationships between condoms, hormonal methods, and sexual pleasure and satisfaction: an exploratory analysis from the Women\'s Well - Being and Sexuality Study. Sex Health 2008; 5 (4): 321–30.]