GynecologyGynecology2079-56962079-5831Consilium Medicum28210Research ArticleThe use of human placenta hydrolyzate in the treatment of insufficient endometrial proliferationKuznetsovaI Vms_smith@list.ruShevelevaT V-PobedinskayaO S-UspenskayaY B-GilelsA V-15062013153293309042020Copyright © 2013, Consilium Medicum2013Endometrium dysfunction on the chronic endometritis background is a major cause of infertility and pregnancy loss. The effectiveness of chronic modern endometritis treatment methods is limited. In its basis, the chronic endometritis therapy is a directed action that can reduce the excessive endometrial inflammatory response while reinforcing its regenerative capabilities. The following paper presents the results of the randomized, open and comparative study of the human placenta hydrolyzate Laennek® when treating patients with chronic endometritis and/or failure of endometrial function. Also, the more effective placenta hydrolyzate use for the restoration of endometrial thickness, ovarian function in women with infertility and recurrent miscarriage compared with therapy hepatoprotectors vnitaminnymi and immunomodulatory drugs is demonstrated. Laennek® ‘s positive impact in pregravidal preparation of patients with chronic endometritis by the modulating effects on the immune and inflammatory processes, growth and function of endometrial ovarian autocrine and paracrine regulation.chronic endometritisinfertilitymiscarriageendometrial dysfunctionplacenta hydrolyzateLaennekхронический эндометритбесплодиеневынашивание беременностиэндометриальная дисфункциягидролизат плацентыЛаеннек[Сухих Г.Т., Шуршалина А.В. Хронический эндометрит: руководство. М.: ГЭОТАР - Медиа, 2013.][Miwa I, Tamura H, Takasaki A et al. Pathophysiologic features of «thin» endometrium. Fertil Steril 2009; 91 (4): 998–1004.][Пасман Н.М., Черных Е.Р., Хонина Е.А. и др. Иммунный статус женщин группы высокого риска по преждевременному прерыванию беременности. Вопр. гинекологии, акушерства и перинатологии. 2010; 9 (4): 28–32.][Громова О.А., Торшин И.Ю., Диброва Е.А. и др. Мировой опыт применения препаратов из плаценты человека: результаты клинических и экспериментальных исследований. Обзор. Пластическая хирургия и косметология. 2011; 3: 385–576.][Chakraborty P.D, Bhattacharyya D, Pal S, Ali N. In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract. Int Immunopharmacol, 2006; 6 (1): 100–7.][Жидоморов Н., Суракова Т., Гришина Т., Громова О.А. Экспериментальное исследование влияния препарата Лаеннек на процессы регенерации в коже. Less nouvelles esthetiques 2011; 3: 2–6.][Dharmarajan A.M, Goodman S.B, Atiya N et al. Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental - derived factors in promoting luteal cell survival. Apoptosis 2004; 9 (6): 807–14.][Richter K.S, Bugge K.R, Bromer J.G, Levy M.J. Relationship between endometrial thickness and embrio implantation, based on 1294 cycles of in vitro fertilization with transfer of two blastocyst - stage embryos. Fertil Steril 2007; 87: 53–9.][Шуршалина А.В. Хронический эндометрит у женщин с патологией репродуктивной функции. Автореф. дис. … д - ра мед. наук. М., 2007.]