GynecologyGynecology2079-56962079-5831Consilium Medicum28218Research ArticleThe effectiveness of chronic pelvic pain treatment in patients with endometriosis depending on the estrogen metabolite levelsManukhinI B-ProhorovaM V-GevorkyanM A-ManukhinaE I-SmirnovaS O-15082013154161809042020Copyright © 2013, Consilium Medicum2013This article presents the results of studies 58 patients, mean age 29±1,7 years with chronic pelvic pain and laparoscopically confirmed diagnosis of external genital endometriosis. Based on the research results of estrogen metabolites has been allocated two groups studied patients. Group I – 26 patients (44,8%) with a predominance of carcinogenic fractions of estrogen in the urine of 2-ONE1/16-ONE1 least 2 (average 0,8±0,2), II group – 54 patients (55,2%) with normal estrоgen metabolism (average 2,3±0,3). Against the background of suppressive therapy with dienogest 2 mg after surgery in 12 months was significant (p<0,05) reduction in pelvic pain VAS.pelvic painendometriosislaparoscopyestrogen metabolitessuppressive therapydienogestтазовая больэндометриозлапароскопияметаболиты эстрогеновсупрессивная терапиядиеногест[Adamson G.D, Hummelshoj L. Creating solutions in endometriosis: global callsboration through the World Endometriosis Reserch Foundation. J Endometriosis 2010; 2: 3–6.][SOGC Clinical Practice Guidelin (II-3) 244, 2010.][Ашрафян Л.А., Киселев В.И., Муйжнек Е.Л. Патогенетическая профилактика рака репродуктивных органов. М.: Молодая гвардия, 2009.][Neil P. Johnson. Lone Hummelshoj Consensus on current management of endometriosis for the World Endometriosis Society Montpellier Consortium. Hum Reprod first published online July 12, 2013 doi:10.1093/humrep/det282][Nnoaham K.E, Hummelshoj L, Webster P et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril 2011; 96 (2): 366–73.][Moniek M. ter Kuile, Philomeen T.M Weijenborg, Spinhoven P. Sexual Functioning in Women with Chronic Pelvic Pain: The Role of Anxiety and Depression J Sex Med 2010; 7: 1901–10.][Sepulcri R de P, do Amaral V.F. Depressive symptoms, anxiety, and quality of life in women with pelvic endometriosis. Eur J Obstet Gynecol Reprod Biol 2009; 142 (1): 53–6. Epub 2008 Nov 17.][Смулевич А.Б. Депрессии при соматических и психических заболеваниях. М., 2003.][Wheeler J.M. Epidemiology and prevalence of endometriosis. Infertil Reprod Med Clin North Am 1992; 3: 545–9.][Адамян Л.В., Кулаков В.И., Андреева Е.Н. Эндометриозы. М.: Медицина. 2006; 416.][Kennedy S.H, Mardon H.J, Barlow D.H. Familial endometriosis. J Ass Reprod Genet 1995; 72: 32–4.][Pascual M. Role of color Doppler ultrasonography in the diagnosis of endometriotic cyst. J Ultrasound Med 2000; 19: 695–9.][Манухин И.Б., Тумилович Л.Г., Геворкян М.А. Клинические лекции по гинекологической эндокринологии. М.: ГЭОТАР - Медиа, 2013.][El-Sahwi K, El-Faham M, Ei-Sahwi S. Laparoscopic management of ovarian endometriomas: incision peeling versus coagulation. Proceedings of XIX World Congress on Fertility & Sterility. Durban, South Africa, 2007; FC1502: 78; Koninckx P.R, Barlow D.][Shimizu Y et al. Steroids 2011; 76 (1–2): 60–7.][Redwine D.B, Wright J.T. Laparoscopic treatment of complete obliteration of the cul - de - sac associated with endometriosis: long - term follow - up of en bloc resection. Fertil Steril 2001; 76: 358–65.][Leyland N et al. J Obstet Gynaecol Can 2010; 32: S1–S32; Deutsche Gesellschaft fuer Gynaekologie and Geburtshilfe e.V. Diagnostik und Therapie der Endometriose (S1). 2010; Fertility and Sterility R Vol. 97, No. 2, February 2012 0015-0282.]