GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum28227ArticlesСтатьиResearch ArticleSravnitel'noe kontroliruemoe randomizirovannoe issledovanie otsenki effektivnosti dvukhetapnogo lecheniya bakterial'nogo vaginozaСравнительное контролируемое рандомизированное исследование оценки эффективности двухэтапного лечения бактериального вагинозаSavichevaAlevtina MikhaylovnaСавичеваАлевтина Михайловна

д-р мед. наук, проф., зав. лаб. микробиологии

savitcheva@mail.ruShalepoKira ValentinovnaШалепоКира Валентиновна

канд. биол. наук, ст. науч. сотр. лаб. микробиологии

NazarovaVeronika ViktorovnaНазароваВероника Викторовна

врач-бактериолог лаб. микробиологии

MenukhovaYuliya NikolaevnaМенуховаЮлия Николаевна

врач акушер-гинеколог женской консультации

ФГБУ Научно-исследовательский институт акушерства и гинекологии им. Д.О.Отта СЗО РАМН, Санкт-ПетербургЖенская консультация №34 СПб ГУЗ Городская поликлиника №3415102013155VOL 15, NO5 (2013)ТОМ 15, №5 (2013)121509042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/28227

Проведено сравнительное исследование эффективности лечения бактериального вагиноза (БВ) с применением препарата Гинофлор Э. Гинофлор Э способствует восстановлению физиологического микробиоценоза влагалища после лечения БВ антисептическими препаратами. Терапевтическая и микробиологическая эффективность препарата Гинофлор Э составила 80,8% сразу после окончания терапии и 72,6% через 2–3 нед после окончания лечения. В группе с применением препарата Гинофлор Э раньше восстанавливаются лактобациллы, в основном Lactobacillus crispatus, и их количество не уменьшается после окончания лечения.

бактериальный вагинозлечениеГинофлор ЭSchwebke J.R, Weiss H.L. Interrelationships of bacterial vaginosis and cervical inflammation. Sex Transm Dis 2002; 29: 59–64.Wiesenfeld H.C, Hillier S.L, Krohn M.A et al. Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. Clin Infect Dis 2003; 36: 663–8.Allsworth J.E, Peipert J.F. Severity of bacterial vaginosis and the risk of sexually transmitted infection. Am J Obstet Gynecol 2011; 205 (2): 113: e1–6.Cherpes T.L, Meyn L.A, Krohn M.A et al. Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis. Clin Infect Dis 2003; 37: 319–25.Myer L, Kuhn L, Stein Z.A et al. Intravaginal practices, bacterial vaginosis, and women’s susceptibility to HIV infection: epidemiological evidence and biological mechanisms. Lancet Infect Dis 2005; 5: 786–94.Sweet R.L. Role of bacterial vaginosis in pelvic inflammatory disease. Clin Infect Dis 1995; 20 (Suppl. 2): S271–5.Hillier S.L, Kiviat N.B, Hawes S.E et al. Role of bacterial vaginosis - associated microorganisms in endometritis. Am J Obstet Gynecol 1996; 175: 435–41.Wiesenfeld H, Hillier S, Krohn M et al. Lower genital tract infection and endometritis: Insight into subclinical pelvic inflammatory disease. Obstet Gynecol 2002; 100: 456–63.Haggerty C.L, Hillier S.L, Bass D.C, Ness R.B. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. Clin Infect Dis 2004; 39: 990–5.Ralph S.G, Rutherford A.J, Wilson J.D. Influence of bacterial vaginosis on conception and miscarriage in the first trimester: cohort study. BMJ 1999; 319: 220–3.Mc Gregor J.A, French J.I, Jones W et al. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. Am J Obstet Gynecol 1994; 170: 1048–59.Hay P.E, Lamont R.F, Taylor-Robinson D et al. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 1994; 308: 295–8.Kurki T, Sivonen A, Renkonen O.V et al. Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol 1992; 80: 173–7.Lamont R.F, Taylor-Robinson D, Newman M et al. Spontaneous early preterm labour associated with abnormal genital bacterial colonization. Br J Obstet Gynaecol 1986; 93: 804–10.Hillier S.L, Nugent R.P, Eschenbach D.A et al. Association between bacterial vaginosis and preterm delivery of a low - birth - weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995; 333: 1737–42.Silver H.M, Sperling R.S, St Clair P.J, Gibbs R.S. Evidence relating bacterial vaginosis to intraamniotic infection. Am J Obstet Gynecol 1989: 161: 808–12.Workowski K.A, Berman S. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010; 59: 1–110.Ведение больных инфекциями, передаваемыми половым путем, и урогенитальными инфекциями – клинические рекомендации. Под ред. Экспертного совета Российского общества дерматовенерологов и косметологов. Председатель А.А. Курбанова. М., 2012.Koumans E.H, Sternberg M, Bruce C et al. The prevalence of bacterial vaginosis in the United States, 2001–2004: associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis 2007; 34: 864–9.Li J et al. Importance of vaginal microbes in reproductive health. Reprod Sci 2012; 19 (3): 235–42.Antonio M.A, Hawes S.E, Hillier S.L. The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species. J Infect Dis 1999; 180 (6): 1950–6.Jespers V et al. Quantification of bacterial species of the vaginal microbiome in different groups of women, using nucleic acid amplification tests. BMC Microbiol 2012; 12: 83.Lamont R et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG 2011; 118: 533–49.Vasquez A et al. Vaginal Lactobacillus flora of healthy Swedish women. J Clin Microbiol 2002; 40 (8): 2746–9.Lamont R, Sobel J, Akins R et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG 2011; 118: 533–49.Larsson P.G, Brandsborg E, Hammarström L. Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses. BMC Infect Dis 2011; 11: 22.http://www2a.cdc.gov/stdtraining/ready-to-use/Manuals/Vaginitis/ vaginitis-slides-2013.pdf