GynecologyGynecology2079-56962079-5831Consilium Medicum28247Research ArticleFolate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunctionTapilskayaN Itapnatalia@yandex.ruGaidukovS N-15062013153707409042020Copyright © 2013, Consilium Medicum2013Endothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeostasis depletion, namely, in a long flowing hyperhomocysteinemia by an imbalance in the antioxidant system of the body leads to a decrease in the number of endothelial progenitor cells, which reduces the regenerative capacity and plasticity of the vascular wall. Hyperhomocysteine when administered in excessive concentrations leads to inhibition of sodium-potassium adenosinetriphosphatase in the membrane of vascular smooth muscle cells, increasing intracellular sodium concentration, and thus leading to electrolyte disturbances that cause vasoconstriction becoming and essential element is a vicious circle of the underlying pathogenesis of both hypertension and preeclampsia. The use of contraceptives containing biologically active folate metafolin on preconception stage is a part of a targeted approach to the prevention of complications of pregnancy in women of reproductive age.homocysteineendothelial dysfunctionmetafolincombined oral contraceptives, folate containingгомоцистеинэндотелиальная дисфункцияметафолинкомбинированные оральные контрацептивы, содержащие фолаты[Петрищев H.H., Власов Т.Д. Тромбогенные и тромборезистентные свойства эндотелия. Система гемостаза. Под ред. H.H.Петрищева. 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