GynecologyGynecology2079-56962079-5831Consilium Medicum28259Research ArticleVitamin and mineral status correction in pregnant women with a high risk of macrosomiaShikhE Vchih@mail.ruGrebenschikovaL Yuludazdrav@mail.ru15082013154596409042020Copyright © 2013, Consilium Medicum2013Purpose. Optimizing the correction of vitamin and mineral status in pregnant women with a high risk of macrosomia. Patients. 1308 female patients were examined at 23–24 weeks of pregnancy. Increased risk of macrosomia was diagnosed in 527 pregnant women. Two groups were formed: first group, consisting of 280 women who were not taking any vitamin-mineral complexes (VMC) at the diagnosis time, and the 2nd group, consisting of 247 women receiving VMCs since the establishment of pregnancy. Methods. Quantitative determination of zinc (Zn) was performed by mass spectrometry, whereas vitamins such as A, E – by means of the high performance liquid chromatography (HPLC), and vitamin C – using the Farmer-Abt method. For early macrosomia prediction the «method of predicting birth of a large fetus» was used (patent number 2,428,118 as of 18.01.2010). Results. In the first group at 23–24 weeks' gestation revealed the following changes in element reduction: in Zn provision in 72,5% of the cases, in B12 vitamin in 70,3%, in B1 vitamin in 65,8%, in B9 vitamin – in 63,9%, and vitamin C – in 54,6%. Upon VMC prescription to the group of pregnant women from 24 weeks of pregnancy up to the delivery the normal physiological levels of Zn, at the lower boundary level of vitamins B1, B12, B6, B9 are not restored. In pregnant women who received the VMC Alphabet Mommy's health a statistically significantly higher provision of Zn and vitamin B9, compared to a group of pregnant women who received single-pill VMC was noted. Conclusion. In the event of receiving VMC at 23–24 weeks of pregnancy the VMC produced with interactions should be preferred in order to increase the vitamin B9 and Zn provision.vitamin-mineral complexinteractionmacrosomiazincfolic acidвитаминно-минеральный комплексвзаимодействиемакросомияцинкфолиевая кислота[Абрамченко В.В. Беременность и роды высокого риска. М.: Медицинское информационное агентство, 2004.][Donma M.M. Macrosomia, top of the iceberg: the charm of underlying factors. Pediatr Int 2010.][Ахмина Н.И., Охлопков К.А. Значение витаминов и микроэлементов при беременности. Лечащий врач. 2005; 10: 7–14.][Ferbег А. Маtеrnal соmplications of fetal macrosomia. Сlin Obstet Gynecol 2000; 43: 335–39.][Lahmann P.H, Wills R.A, Coory M. Trends in birth size and macrosomia in Queensland, Australia, from 1988 to 2005. Paediatr Perinat Epidemiol 2009; 23 (6): 533–41.][Громова О.А., Торшин И.Ю., Авдеева Н.В., Спиричев В.Б. Опыт применения витаминов и микроэлементов у беременных в разных странах. Cons. Med. 2011; 6: 20–7.][Драгун И.Е., Михайлова О.И. Обоснование применения витаминно - минеральных комплексов у беременных. РМЖ. 2008; 16 (19): 12–9. Мать и дитя. Акушерство и гинекология. Специальный номер.][Urgell M.R, Benavides J.F, Gonzalez de Aguero Laborda R. Maternal nutritional factors: significance for the fetus and the neonate. Early Hum Dev 2012; 53: 61–76.][Ших Е.В., Ильенко Л.И. Клинико - фармакологические аспекты применения витаминно - минеральных комплексов у женщин в период беременности. Учебное пособие. М.: МЕДПРАКТИКА - М, 2007.][Lind T, Lonnerdal B, Stenlund H. A community - based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. Am J Clin Nutr 2004; 80 (3):729–36.][Громова О.А., Торшин И.Ю. Применение фолиевой кислоты в акушерско - гинекологической практике. РСЦ Института микроэлементов ЮНЕСКО, 2009; с. 56.][Блинков И.Л., Стародубцев А.К., Сулейманов С.Ш., Ших Е.В. Микроэлементы: Краткая клиническая энциклопедия. Хабаровск, 2004.][Sandstrom B, Lonerdal B. Promoters and antagonists of zinc absorption. Am J Biol 2009; 5: 57–78.][Solomons N.W. Competitive interactions of iron and zinc in the diet. J Nutr 2008; 116: 927–35.]