GynecologyGynecology2079-56962079-5831Consilium Medicum28341Research ArticleMagnesium deficit and muscular convulsions in pregnant women. Therapeutic possibilities. (clinico-pharmacological lecture)GromovaO AUnesco.gromova@gmail.comLimanovaO A-15042014162707709042020Copyright © 2014, Consilium Medicum2014The article discusses the biochemistry of muscle contraction, physiological role of magnesium deficiency, and its connection with seizures, magnesian therapy and synergistic effect of magnesium and its pharmacological carriers, such as pidolate and citrate usecrampsmagnesiumpregnantMagne B6 ForteсудорогимагнийбеременностьМагне В6 форте[Видаль. Лекарственные препараты в России. Справочник. М.: АстраФармСервис, 2014.][Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006.][Громова О.А., Кудрин А.В. Нейрохимия макрои микроэлементов. М.: Алев-В, 2001.][Громова О.А., Торшин И.Ю., Гришина Т.Р. Мировой опыт применения цитрата магния и пиридоксина. Фарматека. 2010; 10.][Громова О.А., Лиманова О.А., Торшин И.Ю. Систематический анализ фундаментальных и клинических исследований как обоснование необходимости совместного использования эстрогенсодержащих препаратов с препаратами магния и пиридоксина. Акуш., гинекол. и репрод. 2013; 3: 35-50.][Дадак К. Дефицит магния в акушерстве и гинекологии. Акуш., гинекол. и репрод. 2013; 2: 3-8, 6-14.][Макацария А.Д., Бицадзе В.О., Хизроева Д.Х., Джобава Э.М. Распространенность дефицита магния у беременных женщин, наблюдающихся в условиях амбулаторной практики. Вопр. гинекол. акуш. и перинатол. 2012; 11 (5).][Серов В.Н., Сухих Г.Т. Клинические рекомендации. Акуш. и гинекол. М.: ГЭОТАР-Медиа, 2014.][Торшин И.Ю., Громова О.А. 25 мгновений молекулярной фармакологии. М.: А-Гриф, 2012.][Ariza А.С, Bobadilla N, Dtaz L et al. Placental gene expression of calcitonin generelated peptide and nitric oxide synthases in preeclampsia: effects of magnesium sulfate. Magnes Res 2009; 22 (1): 44-9.][Barbagallo M, Dominguez L.J, Galioto A et al. Oral magnesium supplementation improves vascular function in elderly diabetic patients. Magnes Res 2010; 23 (3): 131-7.][Chubanov V, Waldegger S, Mederos et al. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causeshypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci USA 2004; 101 (9): 2894-9.][Duley L, Gülmezoglu A.M, Chou D. Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev 2010; 9: CD002960.][Dusticier N, Kerkerian L, Errami M, Nieoullon A. Effects of pyroglutamic acid on corticostriatalglutamatergic transmission. Neuropharmacology 1985; 24 (9): 903-8.][Gaudreault P, Friedman P.A, Lovejoy F.H.Jr. Efficacy of activated charcoal and magnesium citrate in the treatment of oral paraquat intoxication. Ann Emerg Med 1985; 14 (2): 123-5.][Coudray C, Rambeau M, Feillet-Coudray C et al. Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg - depleted rats using a stable isotope approach. Magnes Res 2005; 18 (4): 215-23.][Grazzi L, Andrasik F, Usai S, Bussone G. Magnesium as a preventive treatment for paediatric episodic tension - type headache: results at 1-year follow - up. Neurol Sci 2007; 28 (3): 148-50.][Hadjistavri L.S, Sarafidis P.A, Georgianos P.I et al. Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile. Med Sci Monit 2010; 16 (6): CR307-CR312.][Hankins J.S, Wynn L.W, Brugnara C et al. Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia. Br J Haematol 2008; 140 (1): 80-5.][Li Y. Magnesium status and dietary intake of mid - old people in a rural area of China. Magnes Res 2009; 22 (2): 66-71.][Meij I.C, Koenderink J.B, van Bokhoven H et al. Dominant isolated renal magnesium loss is caused by misrouting of the Na(+), K(+)-ATPase gamma - subunit. Nat Genet 2000; 26 (3): 265-6.][Pepe S, Leong J, van der Merwe J et al. Targeting oxidative stress in surgery: effects of ageing and therapy. Exp Gerontol 2008; 43 (7): 653-7.][Schlingmann K.P, Konrad M, Seyberth H.W. Genetics of hereditary disorders of magnesium homeostasis. Pediatr Nephrol 2003; p. 2110-5.][Sriboonlue P, Jaipakdee S, Jirakulsomchok D et al. Changes in erythro cyte contents of potassium, sodium and magnesium and Na, K-pump activity after the administration of potassium and magnesium salts. J Med Assoc Thai 2004; 87 (12): 1506-12.][Torshin I, Gromova O. Magnesium: fundamental studies and clinica practice. Nova Biomed Pub. NY, 2011.][Wang M, Yang Y, Dong Z et al. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long - term potentiation/long - term depression in vivo. Neuroreport 2006; 17 (12): 1343-6.][Young G.L, Jewell D. Interventions for leg cramps in pregnancy. Cochrane atabase of Systematic Reviews 2002. Issue 1. Art. No.: CD000121. DOI: 10.1002/14651858. CD000121.]