<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">28459</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The possibility of reducing the risk of developing preeclampsia (review of foreign literature)</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности снижения риска развития преэклампсии(обзор зарубежной литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Levakov</surname><given-names>S A</given-names></name><name xml:lang="ru"><surname>Леваков</surname><given-names>С А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borovkova</surname><given-names>E I</given-names></name><name xml:lang="ru"><surname>Боровкова</surname><given-names>Е И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sheshukova</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Шешукова</surname><given-names>Н А</given-names></name></name-alternatives><email>dr.sheshukova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2015</year></pub-date><volume>17</volume><issue>3</issue><issue-title xml:lang="en">VOL 17, NO3 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 17, №3 (2015)</issue-title><fpage>52</fpage><lpage>53</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/28459">https://gynecology.orscience.ru/2079-5831/article/view/28459</self-uri><abstract xml:lang="en"><p>The article presents a review of international literature on the possibilities of prevention of pre-eclampsia in women at high risk. Given data from recent randomized trials and meta-analyses, have confirmed whether the use of low-dose antiplatelet therapy with 12 weeks of pregnancy to prevent the development of pre-eclampsia.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен обзор зарубежной литературы, посвященный возможностям профилактики развития преэклампсии у женщин из группы высокого риска. Приведены данные последних рандомизированных исследований и метаанализов, подтвердивших целесообразность назначения низких доз антиагрегантов с 12 нед беременности для профилактики развития преэклампсии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>antiplatelet agents</kwd><kwd>prevention</kwd><kwd>pre-eclampsia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>антиагреганты</kwd><kwd>профилактика</kwd><kwd>преэклампсия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Low - dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy - induced hypertension. Italian study of aspirin in pregnancy. Lancet 1993; 341: 396.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Caritis S, Sibai B, Hauth J et al. Low - dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 1998; 338: 701.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>CLASP: a randomised trial of low - dose aspirin for the prevention and treatment of pre - eclampsia among 9364 pregnant women. CLASP (Collaborative Low - dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 1994; 343: 619.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Duley L, Henderson-Smart D.J, Meher S, King J.F. Antiplatelet agents for preventing pre - eclampsia and its complications. Cochrane Database Syst Rev 2007; CD004659.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Dekker G, Sibai B. Primary, secondary, and tertiary prevention of pre - eclampsia. Lancet 2001; 357: 209.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Coomarasamy A, Honest H, Papaioannou S et al. Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. Obstet Gynecol 2003; 101: 1319.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bates S.M, Greer I.A, Middeldorp S et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e691S.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bushnell C, Mc Cullough L.D, Awad I.A et al. Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2014.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Barton J.R, Sibai B.M. Prediction and prevention of recurrent preeclampsia. Obstet Gynecol 2008; 112: 359.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Askie L.M, Duley L, Henderson-Smart D.J et al. Antiplatelet agents for prevention of pre - eclampsia: a meta - analysis of individual patient data. Lancet 2007; 369: 1791.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Roberge S, Nicolaides K.H, Demers S et al. Prevention of perinatal death and adverse perinatal outcome using low - dose aspirin: a meta - analysis. Ultrasound Obstet Gynecol 2013; 41: 491.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Meher S, Alfirevic Z. Aspirin for pre - eclampsia: beware of subgroup meta - analysis. Ultrasound Obstet Gynecol 2013; 41: 479.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Sibai B.M, Caritis S.N, Thom E et al. Prevention of preeclampsia with low - dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 1993; 329: 1213.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Subtil D, Goeusse P, Puech F et al. Aspirin (100 mg) used for prevention of pre - eclampsia in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 1). BJOG 2003; 110: 475.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sibai B, Dekker G, Kupferminc M. Pre - eclampsia. Lancet 2005; 365: 785.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Villa P.M, Kajantie E, Raikkonen K et al. Aspirin in the prevention of pre - eclampsia in high - risk women: a randomised placebo - controlled PREDO Trial and a meta - analysis of randomised trials. BJOG 2013; 120: 64.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Obstet Gynecol 2013; 122: 1122.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Knight M, Duley L, Henderson-Smart D.J, King J.F. Antiplatelet agents for preventing and treating pre - eclampsia. Cochrane Database Syst Rev 2000; CD000492.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Visintin C, Mugglestone M.A, Almerie M.Q et al. Management of hypertensive disorders during pregnancy: summary of NICE guidance. BMJ 2010; 341: c2207.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Bujold E, Roberge S, Lacasse Y et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta - analysis. Obstet Gynecol 2010; 116: 402.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Hirsh J, Guyatt G, Albers G.W et al. Executive summary: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 71S.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Schiff E, Barkai G, Ben-Baruch G, Mashiach S. Low - dose aspirin does not influence the clinical course of women with mild pregnancy - induced hypertension. Obstet Gynecol 1990; 76: 742.</mixed-citation></ref></ref-list></back></article>
