<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">28472</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">New features in the diagnosis of "lesser" abnormalities of cervical epithelium associated with HPV infection (review of literature)</article-title><trans-title-group xml:lang="ru"><trans-title>Новые возможности диагностики «малых» форм поражений эпителия шейки матки, ассоциированных с папилломавирусной инфекцией (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nazarova</surname><given-names>N M</given-names></name><name xml:lang="ru"><surname>Назарова</surname><given-names>Н М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prilepskaya</surname><given-names>V N</given-names></name><name xml:lang="ru"><surname>Прилепская</surname><given-names>В Н</given-names></name></name-alternatives><email>VPrilepskaya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sycheva</surname><given-names>E G</given-names></name><name xml:lang="ru"><surname>Сычева</surname><given-names>Е Г</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zardiashvili</surname><given-names>M D</given-names></name><name xml:lang="ru"><surname>Зардиашвили</surname><given-names>М Д</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bourmenskaya</surname><given-names>O V</given-names></name><name xml:lang="ru"><surname>Бурменская</surname><given-names>О В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2015</year></pub-date><volume>17</volume><issue>5</issue><issue-title xml:lang="en">VOL 17, NO5 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 17, №5 (2015)</issue-title><fpage>32</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/28472">https://gynecology.orscience.ru/2079-5831/article/view/28472</self-uri><abstract xml:lang="en"><p>In this review we observed the role of high risk HPV types in the development of epithelial lesions of the cervix. Modern data on the role of molecular genetic methods in the diagnosis of HPV-associated diseases are represented here. We analyze the literature on modern molecular biomarkers that shows the risk of proliferative processes in the transformation to neoplasia.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре рассмотрена роль высокоонкогенных типов вируса папилломы человека (ВПЧ) в развитии поражений эпителия шейки матки. Представлены современные данные о роли молекулярно-генетических методов исследования в диагностике ВПЧ-ассоциированных заболеваний. Анализируется литература о современных молекулярных биомаркерах, которые отражают риск развития пролиферативных процессов с переходом в неоплазии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>human papillomavirus</kwd><kwd>cervical intraepithelial neoplasia</kwd><kwd>cervix</kwd><kwd>molecular genetic markers</kwd><kwd>E6/E7 mRNA</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вирус папилломы человека</kwd><kwd>цервикальные интраэпителиальные неоплазии</kwd><kwd>шейка матки</kwd><kwd>молекулярно-генетические маркеры</kwd><kwd>мРНК Е6/Е7</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Золотоверхая Е.А. Молекулярные маркеры онкогенной активности вируса папилломы человека: Автореф. дис. ... канд. мед. наук. Спб, 2009.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Lehtinen M. Интеграция вакцины против вирусов папилломы человека в национальные программы иммунизации. Европейский журн. по секс. и репрод. здоровью. 2007; 64: 12.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Waxman A.G, Chelmow D, Darragh T.M et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465-71.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Doorbar J, Egawa N, Griffin H. Human papillomavirus molecular biology and disease association. Rev Med Virol 2015; 25: 2-23.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Cricca M, Morselli-Labate A.M, Venturoli S et al. Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high - grade cervical lesions. Gynecol Oncol Res 2007; 106 (3): 49-57.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Lethaby A, Brown J, Marjoribanks et al. Phytoestrogens for vasomotor menopausal symptoms. Cochran Database Syst Rev 2007: CD001395</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Куевда Д.А., Шипулина О.Ю. Генодиагностика папилломавирусной инфекции высокого канцерогенного риска. Количественный подход. Патология шейки матки и генитальная инфекция. Т. 3. М., 2007; c. 108-19.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kapeu A.S, Luostarinen T, Jellum E et al. Is Smoking an Independent Risk Factor for Invasive Cervical Cancer? A Nested Case-Control Study Within Nordic Biobanks. Am J Epidemiol 2009; 169 (4): 480-8.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sørbye S.W, Fismen S, Gutteberg T.J et al. Triage of women with minor cervical lesions: data suggesting a "test and treat" approach for HPV E6/E7 mRNA testing. PLoS One 2010; 5 (9): e12724.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Ghittoni R, Accardi R, Chiocca S et al. Role of human papillomaviruses in carcinogenesis. ecancer 2015, 9: 526.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2 (5): 342-50.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Bosch F.X et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group [see comments] J Natl Cancer Inst 1995; 87 (11): 796-802.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Munoz N et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348 (6): 518-27.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>De Sanjose S et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective crosssectional worldwide study. Lancet Oncol 2010; 11 (11): 1048-56.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Smith J.S et al. Human papillomavirus type distribution in invasive cervical cancer and high - grade cervical lesions: a meta - analysis update Int J Cancer 2007; 121 (3): 621-32.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>von Knebel-Döberitz M, Syrjänen K. Molecular markers. How to apply in practice. Gynecol Oncol 2006; 103: 18-20.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Szoke K, Sapy T, Krasznai Z et al. Moderate variation of the oncogenic potential among high - risk human papillomavirus types in gynecologic patients with cervical abnormalities. J Med Virol 2003; 71: 585-92.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Molano M, van den Brulel A, Plummer M et al. Determinants of Clearance of Human Papillomavirus Infections in Colombian Women with Normal Cytology: A Population - based, 5-Year Follow - up Study. Am J Epidemiol 2003; 158 (5): 486-94.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Schneider A et al. Screening for cervical intraepithelial neoplasia grade 2/3: validity of cytologic study, cervicography, and human papillomavirus detection. Am J Obstet Gynecol 1996; 174 (5): 1534-41.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Grce M, Davies P. Human papillomavirus testing for primary cervical cancer screening. Expert Rev Mol Diagn 2008; 8 (5): 599-605.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Mandelblatt J.S, Lawrence W.F, Womack S.M et al. Benefits and costs of using HPV testing to screen for cervical cancer. JAMA 2002; 287: 2372-81.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Naucler P, Ryd W, Törnberg S et al. Human papillomavirus and Papanicolaou tests to screen for cervical cancer. N Engl J Med 2007; 357: 1589-97.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Schiffman M, Wentzensen N. From Human papillomavirus to cervical cancer. Obstet Gynecol 2010; 116 (1): 177-85.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Sorbye S.W, Fismen S, Gutteberg T.J et al. HPV mRNA test in women with minor cervical lesions: experience of the University Hospital of North Norway. J Virol Methods 2010; 169: 219-2.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Tropé A, Sjoborg K, Eskild A et al. Performance of Human Papillomavirus DNA and mRNA Testing Strategies for Women with and without Cervical Neoplasia. J Clin Microbiol 2009; 47 (8): 2458-64.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Castle P.E, Fetterman B, Poitras N et al. Variable risk of cervical precancer and cancer after a human papillomavirus - positive test. Obstet Gynecol 2011; V (117); 650-6.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Ho G.Y, Bierman R, Beardsley L et al. Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 1998; 338: 423-28.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Sankaranarayanan R et al. HPV screening for cervical cancer in rural India N Engl J Med 2009; 360 (14): 1385-94.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Tropé A, Sjoborg K.D, Nygård M et al. Cytology and human papillomavirus testing 6 to 12 months after ASCUS or LSIL cytology in organized screening to predict high - grade cervical neoplasia between screening rounds. J Clin Microbiol 2012; 50 (6): 1927-35.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Ronco G, Cuzick J, Pierotti P et al. Accuracy of liquid versus conventional cytology: overall results of new technologies for cervical cancer screening: randomized controlled trial. BMJ 2007; 335 (7609): 28.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Moore E.E, Danielewski J.A, Garland S.M et al. Clearance of human papillomavirus in women treated for cervical dysplasia. Obstet Gynecol 2011; 117: 101-8.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Серов В.Н., Баранов И.И. Лечение урогенитальных инфекций у женщин в современных условиях. Рус. мед. журн. 2004; 12 (8): 564-9.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Шабалова И.П., Касоян К.Т. Цитологическая диагностика заболеваний шейки матки и тела матки. 3-е изд., испр. и доп. М.: Триада, 2010.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ronco G, Cuzick J, Pierotti P et al. Accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening randomized controlled trial. BMJ 2007; 5 (7609): 28-38.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Роговская С.И. Папилломавирусная инфекция у женщин и патология шейки матки: в помощь практикующему врачу. М.: ГЭОТАР-Медиа, 2005; 39-42.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Троицкая О.Г. Современные методы диагностики и лечения папилломавирусной инфекции шейки матки у женщин репродуктивного возраста. Автореф. дис. … канд. мед. наук. Спб., 2008.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Arbyn M, Martin-Hirsch P, Buntinx F et al. Triage of women with equivocal or low - grade cervical cytology results: a meta - analysis of the HPV test positivity rate. J Cell Mol Med 2009; 13: 648-59.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Koliopoulos G, Arbyn M, Martin-Hirsch P et al. Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta - analysis of non - randomized studies. Gynecol Oncol 2007; 104 (1): 232-46.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Сухих Г.Т., Прилепская В.Н. Профилактика рака шейки матки. М.: МЕДпресс - информ, 2012; с. 25-30.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Роговская С.И., Подзолкова Н.М., Минкина Г.Н. Новое в кольпоскопии. Гинекология. 2011; 13 (5): 62-6.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Saslow D, Castle P.E, Cox J.T et al. American Cancer Society Guideline for Human Papillomavirus (HPV) Vaccine Use to Prevent Cervical Cancer and Its Precursors. C A Cancer J Clin 2007; 57: 7-28.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Wentzensen N, Sherman M.E, Schiffman M et al. Utility of methylation markers in cervical cancer early detection: appraisal of the state - of - the - science. Gynecologic Oncology 2009; 112 (2): 293-9.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Nasioutziki M, Daniilidis A, Dinas K et al. The evaluation of p16INK4a immunoexpression/immunostaining and human papillomavirus DNA test in cervical liquid - based cytological samples. Int J Gynecol Cancer 2011; 21 (1): 79-85.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Sørbye S.W, Fismen S, Gutteberg T.J et al. HPV mRNA Is More Specific than HPV DNA in Triage of Women with Minor Cervical Lesions. PLoS One 2014; 9 (1).</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Wang F, Li Y, Zhou J et al. miR-375 is down - regulated in squa - mous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol 2011; 179: 2580-8.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Caraceni D, Ghiringhello B, Keller T et al. p16/ki-67 dual - stain cytology in the triage of ASCUS and LSIL papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology study. Cancer Cytopathol 2011; 119 (3): 158-66.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Possati-Resende J.C, Fregnani J.H, Kerr L.M et al. The Accuracy of p16/Ki-67 and HPV Test in the Detection of CIN2/3 in Women Diagnosed with ASC-US or LSIL. PLoS One 2015; 10 (7).</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Heng Z.M, Wang X. Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta 2011; 1809 (11-12): 668-77.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Molden T, Nygård J.F, Kraus I et al. Predicting CIN2+ when detecting HPV mRNA and DNA by PreTect HPV-Proofer and consensus PCR: a 2-year follow - up of women with ASCUS or LSIL Pap smear. Int J Cancer 2005; 114 (6): 973-6.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Cuzick J, Cadman L, Mesher D et al. Comparing the performance of six human papillomavirus tests in a screening population. Br J Cancer 2013; 108: 908-13.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Cattani P, Zannoni G.F, Ricci C et al. Clinical performance of human papillomavirus E6 and E7 mRNA testing for high - grade lesions of the cervix. J Clin Microbiol 2009; 47: 3895-01.</mixed-citation></ref></ref-list></back></article>
