GynecologyGynecology2079-56962079-5831Consilium Medicum28515Research ArticlePossible therapy of miscarriageDobrokhotovaYu E-DzhokhadzeL SAnton-b1@mail.ruKopylovaYu V-N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation15022016181687009042020Copyright © 2016, Consilium Medicum2016The article provides a comparative evaluation of different methods of treatment of preterm labor. It analyzed the effectiveness of therapy, and outcomes of 45 pregnant women who are in therapy as preterm labor carried an acute intravenous tocolysis, and then move on to maintenance tocolysis in combination with the intravaginal application of micronized natural progesterone. A control group comprised 42 patients, who spend only acute tocolysis. We believe that the preferred replacement of pregnant women with acute tocolysis to tocolytic therapy to supportive tablet form while using micronized form of progesterone.preterm labortocolysiseffectivenessprogesteronetherapyпреждевременные родытоколизэффективностьпрогестеронтерапия[Di Renzo G.C, Giardina I, Rosati A et al. Maternal risk factors for preterm birth: a country - based population analysis. Italian Preterm Network Study Group. Eur J Obstet Gynecol Reprod Biol 2011; 159 (2): 342-6.][Crowther C.A, Brown J, Mc Kinlay C.J, Middleton P. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2014; 8.][Радзинский В.Е. Преждевременные роды и перспективы применения прогестерона для их профилактики. Здоровье женщины. 2013; 3 (79): 96.][Di Renzo G.C, Roura L.C, Facchinetti F. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011; 24 (5): 659-67.][Серов В.Н., Сухорукова О.И. Преждевременные роды - диагностика и терапия. Мед. совет. 2014; 9: 50-3.][Доброхотова Ю.Э., Степанян А.В., Судакова Г.Ю. Микронизированный прогестерон в терапии угрозы преждевременных родов: систематический обзор и мета - анализ рандомизированных и контролируемых исследований. Вопр. гинекологии, акушерства и перинатологии. 2010; 9 (4): 63-70.][Doyle L.W, Anderson P.J, Haslam R et al. School - age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo. Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO4) Study Group. JAMA 2014; 312 (11): 1105-13.][Di Renzo G.C, Giardina I, Clerici G et al. The role of progesterone in maternal and fetal medicine. Gynecol Endocrinol 2012; 28 (11): 925-32.][Gerli S, Favilli A, Giordano C et al. Single indications of induction of labor with prostaglandins and risk of cesarean delivery: a retrospective cohort study. J Obstet Gynaecol Res 2013; 39 (5): 926-31.][Honest H, Forbes C.A, Duree K.H et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009; 13: l-627.][Romero R, Dey S.K, Fisher S.J. Preterm labor: one syndrome, many causes. Science 2014; 345 (6198): 760-5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.][Romero R, Hassan S.S, Gajer P et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. J Microbiome 2014; 2: 18.][Kim Y.M, Chaemsaithong P, Romero R et al. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Midtrimester Spontaneous Abortion. J Matern Fetal Neonatal Med 2014; p. 1-24.][Mc Cubbin K, Moore S, Mac Donald R, Vaillancourt C. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Prehosp Emerg Care 2014.][Мандрыкина Ж.А., Менжинская И.В., Озерова Р.И. и др. Аутосенсибилизация к гормонам при невынашивании беременности. Акушерство и гинекология. 2009; 6: 14-6.][Yuce O, Bicer O.S, Kavuncuoglu S et al. Prematurity, infection, mortality, morbidity and interleukins: the reason or the result of preterm labor? Minerva Pediatr 2014; 66 (6): 563-70.]