GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum28543ArticlesСтатьиResearch ArticleEndre Czeizel and the concept of primary prevention of congenital malformations of the fetusЭндре Цейзель и концепция первичной профилактики врожденных пороков развития плодаDonnikovA EДонниковА Е

канд. мед. наук, вед. науч. сотр. ФГБУ НЦАГиП им. В.И.Кулакова

onnikov@oparina4.ruV.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России15082016184VOL 18, NO4 (2016)ТОМ 18, №4 (2016)263009042020Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/28543

The article describes the history of development of the concept of primary prevention of congenital malformations of the fetus via periconceptional receiving of multivitamin preparations containing folic acid. The results of Hungarian studies on the use of multivitamins are also given below as well as the current understanding of the mechanism of the prophylactic action of folic acid from a position of pharmacogenetics. The data on the use of different biochemical forms of folate is presented as well.

В статье рассмотрена история разработки концепции первичной профилактики врожденных пороков развития плода с помощью периконцепционного приема мультивитаминных препаратов, содержащих фолиевую кислоту. Проанализированы результаты венгерских исследований по использованию мультивитаминов. Даны современные представления о механизме профилактического действия фолиевой кислоты с позиции фармакогенетики. Приведены данные об использовании разных биохимических форм фолатов.

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