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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">28611</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Immunotherapy for recurrent miscarriage due to alloimmune reasons</article-title><trans-title-group xml:lang="ru"><trans-title>Иммунотерапия при привычном выкидыше, обусловленном аллоиммунными причинами</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Saribegova</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Сарибегова</surname><given-names>В А</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, 2-е отд-ние акушерское патологии беременности ФГБУ «НЦАГиП им. акад. В.И.Кулакова»</p></bio><email>saribegova_v@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tetruashvili</surname><given-names>N K</given-names></name><name xml:lang="ru"><surname>Тетруашвили</surname><given-names>Н К</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, рук. 2-го отд-ния акушерского патологии беременности ФГБУ «НЦАГиП им. акад. В.И.Кулакова»</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Krechetova</surname><given-names>L V</given-names></name><name xml:lang="ru"><surname>Кречетова</surname><given-names>Л В</given-names></name></name-alternatives><bio xml:lang="ru"><p>рук. лаб. клинической иммунологии ФГБУ «НЦАГиП им. акад. В.И.Кулакова»</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Agadzhanova</surname><given-names>A A</given-names></name><name xml:lang="ru"><surname>Агаджанова</surname><given-names>А А</given-names></name></name-alternatives><bio xml:lang="ru"><p>вед. науч. сотр. 2-го отд-ния акушерского патологии беременности ФГБУ «НЦАГиП им. акад. В.И.Кулакова»</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. В.И.Кулакова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2017</year></pub-date><volume>19</volume><issue>1</issue><issue-title xml:lang="en">VOL 19, NO1 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 19, №1 (2017)</issue-title><fpage>51</fpage><lpage>55</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/28611">https://gynecology.orscience.ru/2079-5831/article/view/28611</self-uri><abstract xml:lang="en"><p>The article presents the current understanding of the pathogenetic mechanisms of habitual abortion realization of alloimmune genesis and proposed methods of immunotherapy. The mechanisms of the impact and effectiveness of various drugs and cell therapies.</p></abstract><trans-abstract xml:lang="ru"><p>В статье приведены современные представления о патогенетических механизмах реализации привычного выкидыша аллоиммунного генеза и предлагаемые методы иммунотерапии. Рассмотрены механизмы воздействия и эффективность разных лекарственных и клеточных методов лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>habitual miscarriage</kwd><kwd>immunocytotherapy</kwd><kwd>progesterone</kwd><kwd>dydrogesterone</kwd><kwd>T-regulatory cells</kwd><kwd>natural killer cells</kwd><kwd>tolerogenic molecule CD200</kwd><kwd>cytokines</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>привычный выкидыш</kwd><kwd>иммуноцитотерапия</kwd><kwd>прогестерон</kwd><kwd>дидрогестерон</kwd><kwd>Т-регуляторные клетки</kwd><kwd>натуральные киллеры</kwd><kwd>толерогенная молекула CD200</kwd><kwd>цитокины</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Левкович М.А., Линде В.А., Андреева В.О. и др. Иммуно - гормональные взаимодействия в генезе невынашивания беременности ранних сроков. Акушерство и гинекология. 2012; 8 (1): 10-4.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hannan. N.J. 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