GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum28626ArticlesСтатьиResearch ArticleGenetic predisposition to a recurrent course of vulvovaginal candidiasisГенетическая предрасположенность к рецидивирующему течению вульвовагинального кандидозаPogosyanSh MПогосянШ М

аспирант научно-поликлинического отд-ния ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

shaqpoxos@mail.ruMezhevitinovaE AМежевитиноваЕ А

д-р мед. наук, вед. науч. сотр. научно-поликлинического отд-ния ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

DonnikovA EДонниковА Е

канд. мед. наук, зав. лаб. молекулярно-генетических методов ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

PrilepskaiaV NПрилепскаяВ Н

д-р мед. наук, проф., зам. дир. по научной работе, рук. научно-поликлинического отд-ния ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

BurmenskaiaO VБурменскаяО В

д-р биол. наук, науч. сотр. лаб. молекулярно-генетических методов ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

NepshaO SНепшаО С

канд. биол. наук, науч. сотр. лаб. молекулярно-генетических методов ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

BystritskiyA AБыстрицкийА А

канд. биол. наук, науч. сотр. лаб. молекулярно-генетических методов ФГБУ «НМИЦАГиП им. акад. В.И.Кулакова»

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России15082017194VOL 19, NO4 (2017)ТОМ 19, №4 (2017)202509042020Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/28626

Vulvovaginal candidiasis (VVC) frequently occur in women of childbearing age. 5-10% of these women experience recurrent vulvovaginal candidiasis (RVVC), which is characterized by at least 4 episodes of infection in 12 months. In addition to known risk factors such as antibiotics, diabetes, or pregnancy, host genetic variation and antifungal immune response play a substantial role in the pathogenesis of RVVC. The aim of this study was to identify a molecular-genetic factors of recurrence of VVC. Our results shows that single nucleotide polymorphisms (SNP) in cytokine genes such as IL4, IL1b and CCL2 were associated with recurrent vulvovaginal candidiasis and effect on susceptibility to disease.

Вульвовагинальный кандидоз (ВВК) зачастую встречается у женщин репродуктивного возраста. У 5-10% женщин ВВК развивается рецидивирующий ВВК (РВВК), который характеризуется развитием 4 и более эпизодов ВВК в течение 12 мес. Есть данные, что наряду с известными факторами риска, такими как антибактериальная терапия, сахарный диабет, беременность, в патогенезе развития РВВК важную роль принадлежит генетическим особенностям пациенток и противогрибковому иммунному ответу. Целью настоящего исследования явилось выявление молекулярно-генетических факторов рецидивирования ВВК. Результаты нашего исследования показали, что однонуклеотидный полиморфизм генов IL4, IL1b и CCL2 ассоциирован с рецидивирующим вульвовагинальным кандидозом и является предрасполагающим фактором для его развития.

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