GynecologyGynecology2079-56962079-5831Consilium Medicum3004310.26442/2079-5696_20.1.51-56Research ArticleAn infected late miscarriage associated with a genetically determined enhanced immune response in patients with recurrent viral and bacterial infectionsTsechoevaL Shdoctor-leila@yandex.ruGlushakovR Iglushakovruslan@gmail.comTapilskayaN Itapnatalia@yandex.ruI.I.Dzhanelidze Saint Petersburg Research Institute of Emergency MedicineS.M.Kirov Medical Military Academy of the Ministry of Defence of the Russian FederationV.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation15022018201515609042020Copyright © 2018, Consilium Medicum2018Microbiological and genetic examinations of patients previously treated for an infected late miscarriage were performed. Materials and methods. Women (n=36) with viral excretion of cytomegalovirus, bacterial vaginosis, two or more relapses of herpes virus infection localized in the genital area within 6 months, and absence of any other reproductively significant infections were selected. All patients underwent vaginal microbiocenosis studies in dynamics, as well as polymorphisms associated with the enhanced immune response, NOS3 (4a/4b), PAI-1 (4G/5G), IL1B (C3954T, C511T), TNFA (G238A, G308A), PPARG (Pro12Ala), PGC1A (Gly482Ser), GSTM1 (del), GSTT1 (del), MMP1 (1G/2G). Results. In the course of the correlation analysis within the group between qualitative signs (recurrent bacterial vaginosis) and the presence of genetic polymorphisms, it was established that the presence of polymorphisms in matrix metalloproteinase - collagenase-1 (r=0.59) and tumor necrosis factor a (r=0.51) genes is associated with a recurrent course bacterial vaginosis. 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