GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum3009710.26442/2079-5696_20.1.113-116ArticlesСтатьиReview ArticleThickness of endometrium: predictor of the effectiveness of IVF/ICSI programs (literature review)Толщина эндометрия: предиктор эффективности программ ЭКО/ICSI (обзор литературы)BagdasaryanL AБагдасарянЛилит Александровна

аспирант 1-го гинекологического отд-ния

l_bagdasaryan@oparina4.ruKorneyevaI EКорнееваИрина Евгеньевна

д-р мед. наук, доц., ст. науч. сотр. 1-го гинекологического отд-ния

irina.korneeva@inbox.ruV.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationФГБУ «НМИЦ АГП им. акад. В.И.Кулакова»15022018201VOL 20, NO1 (2018)ТОМ 20, №1 (2018)11311609042020Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/30097

The aim of the study is to systematically analyze the data available in the modern literature on the relationship between endometrial thickness and the frequency of pregnancy in the program of assisted reproductive technologies (ART). Materials and methods. The review includes data from foreign and domestic articles found in PubMed on this topic. Results. The article presents data on the relationship between the thickness of the endometrium and the frequency of pregnancy in ART programs. The greatest number of studies is devoted to the evaluation of the relationship between the thickness of the endometrium and the frequency of pregnancy on the day of the ovulation trigger. Data are presented on the existence of a correlation between the thickness of the endometrium measured on the day of the ovulation trigger and the frequency of clinical pregnancy, as well as data on the need to evaluate the structure of the endometrium and the state of subendometric blood flow. The importance of multilayered (three-layered) endometrium as a prognostic marker of success in in vitro fertilization/intracytoplasmic sperm injection programs in the ovum is emphasized. The conclusion. The thickness of the endometrium can not be used as an argument for canceling the cycle or abolishing embryo transfer to the uterine cavity. Further studies in this direction are needed with a study of the morphological and molecular genetic characteristics of the endometrium, which in the future will allow us to evaluate the relationship between the thickness of the endometrium and the probability of pregnancy.

Цель исследования - провести систематический анализ данных, имеющихся в современной литературе, о взаимосвязи между толщиной эндометрия и частотой наступления беременности в программе вспомогательных репродуктивных технологий (ВРТ). Материалы и методы. В обзор включены данные зарубежных и отечественных статей, найденных в PubMed по данной теме. Результаты. В статье приводятся данные о взаимосвязи толщины эндометрия и частоты наступления беременностей в программах ВРТ. Наибольшее число исследований посвящено оценке взаимосвязи толщины эндометрия с частотой наступления беременности в день введения триггера овуляции. Приведены данные о существовании корреляции между толщиной эндометрия, измеренной в день введения триггера овуляции, и частотой клинической беременности, а также данные о необходимости оценки структуры эндометрия и состояния субэндометриального кровотока. Подчеркнута важность наличия многослойного (трехслойного) эндометрия как прогностического маркера успеха в программах экстракорпорального оплодотворения/интрацитоплазматической инъекции сперматозоида в яйцеклетку. Заключение. Толщина эндометрия не может быть использована в качестве аргумента для отмены цикла или отмены переноса эмбриона в полость матки. Необходимы дальнейшие исследования в этом направлении с изучением морфологических и молекулярно-генетических характеристик эндометрия, которые в дальнейшем позволят оценить взаимосвязь между толщиной эндометрия и вероятностью наступления беременности.

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