GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum3396910.26442/20795696.2020.1.200067ORIGINAL ARTICLEОРИГИНАЛЬНАЯ СТАТЬЯResearch ArticleThe experience of using fesoterodine in patients with overactive bladder in the older age groupОпыт применения препарата фезотеродин у пациенток старшей возрастной группы с гиперактивным мочевым пузыремErmakovaElena I.ЕрмаковаЕлена Ивановна
Russian Federation

Candidate of Medical Sciences

канд. мед. наук, ст. науч. сотр. отд. гинекологической эндокринологии

ermakova.health@mail.ruKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России0105202022145490105202001052020Copyright ©; 2020, Consilium MedicumCopyright ©; 2020, ООО "Консилиум Медикум"2020Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/33969

Aim. To evaluate the effectiveness and tolerability of the drug fezoterodin in older patients with оveractive bladder (OAB).

Materials and methods. In 2019, 50 women with OAB aged 50 to 82 years (average age was 67.5±12.5 years) were treated in the framework of donation of the drug fezoterodin (Toviaz). The patients were divided into two groups: group 1 included 25 women had received treatment with fesoterodine dose of 4 mg per day for 12 weeks, group 2 consisted of 25 women, the fesoterodine dose to 8 mg per day for 12 weeks. The diagnosis of OAB was confirmed by a urodynamic study.

Results. 48 (96%) patients out of 50 completed a 12 week course of treatment. The efficacy and tolerability of the drug fezoterodin in both groups was 93.7%. Mild adverse events (dry mouth, constipation, blurred vision) were observed in 11 (22.9%) patients out of 48 treated. None of the women had cognitive impairment (memory impairment, decreased concentration, drowsiness, impaired thinking and orientation).

Conclusion. Our experience with M-cholinoblocator fezoterodin showed statistically and clinically significant improvements in all symptoms of OAB, as well as good tolerability of the drug in patients aged 50 to 82 years.

Цель. Оценить эффективность и переносимость препарата фезотеродин у пациенток старшей возрастной группы с гиперактивным мочевым пузырем (ГАМП).

Материалы и методы. В ФГБУ «НМИЦ АГП им. акад. В.И. Кулакова» в 2019 г. пролечены в рамках донации препарата фезотеродин (Товиаз) 50 женщин с ГАМП в возрасте от 50 до 82 лет (средний возраст составил 67,5±12,5 года). Пациентки были разделены на две группы: 1-я группа (25 женщин) получала терапию фезотеродином в дозе 4 мг/сут 12 нед, 2-я группа (25 женщин) – фезотеродин в дозе 8 мг/сут 12 нед. Диагноз ГАМП подтвержден комплексным уродинамическим исследованием.

Результаты. Завершили 12-недельный курс лечения 48 (96%) пациенток из 50. Эффективность и переносимость препарата фезотеродин в обеих группах составила 93,7%. Нежелательные явления легкой степени (сухость во рту, запоры, нечеткость зрения) наблюдались у 11 (22.9%) пациенток из 48 пролеченных. Ни у одной женщины не отмечено когнитивных нарушений (нарушения памяти, снижения концентрации внимания, сонливости, нарушения мышления и ориентации).

Заключение. Наш опыт применения М-холиноблокатора фезотеродин показал статистически и клинически значимые улучшения в отношении всех симптомов ГАМП, а также хорошую переносимость препарата у пациенток в возрасте от 50 до 82 лет.

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FORTA: система классификации для подбора препаратов, подходящих для пожилых людей; СНМП: симптомы нижних мочевыводящих путей; ГМП: гиперактивный мочевой пузырь. Age Aging 2015. DOI: 10.1093/ageing/afv077 [Oelke M. FORTA: sistema klassifikatsii dlia podbora preparatov, podkhodiashchikh dlia pozhilykh liudei; SNMP: simptomy nizhnikh mochevyvodiashchikh putei; GMP: giperaktivnyi mochevoi puzyr’. Age Aging 2015. DOI: 10.1093/ageing/afv077 (in Russian).]