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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">456458</article-id><article-id pub-id-type="doi">10.26442/20795696.2023.3.202341</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Mastodynia: Current data on the causes, course, diagnosis, and treatment approaches. A review</article-title><trans-title-group xml:lang="ru"><trans-title>Мастодиния. Современные данные о причинах, течении, диагностике и подходах к коррекции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5335-1248</contrib-id><name-alternatives><name xml:lang="en"><surname>Leschenko</surname><given-names>Olga Ya.</given-names></name><name xml:lang="ru"><surname>Лещенко</surname><given-names>Ольга Ярославовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Scientific Centre for Family Health and Human Reproduction Problems</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, гинеколог-эндокринолог, врач высшей категории, гл. науч. сотр. отд. научных технологий</p></bio><email>loyairk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Scientific Centre for Family Health and Human Reproduction Problems</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-10-04" publication-format="electronic"><day>04</day><month>10</month><year>2023</year></pub-date><volume>25</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>282</fpage><lpage>289</lpage><history><date date-type="received" iso-8601-date="2023-05-24"><day>24</day><month>05</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-09-15"><day>15</day><month>09</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/456458">https://gynecology.orscience.ru/2079-5831/article/view/456458</self-uri><abstract xml:lang="en"><p>Mastodynia is a common clinical symptom in general medical and gynecological practice. The objectives of this literature review are to analyze scientific information on the epidemiology of mastodynia/mastalgia, the impact on quality of life, inconsistencies in the etiology determination, to formulate a diagnostic concept, classification, and treatment, and to assess the therapeutic effects of Vitex Agnus-Castus. Scientific publications over the past 30 years were searched in the main research databases, CochraneLibrary, PubMed, Science Direct, Google Scholar, and ELibrary, using the terms "mastalgia," "mastodynia," "Vitex Agnus-Castus," "chest pain," "chest pain, breast pain." The pathophysiology of mastodynia is multifaceted, with various etiology factors and independent ways of pain occurrence. Most studies have emphasized the importance of correctly classifying breast pain for accurate diagnosis and effective therapy to reduce the frequency and severity of pain episodes and improve quality of life while minimizing side effects. Vitex Agnus-Castus is safe and effective in the treatment of mastodynia.</p></abstract><trans-abstract xml:lang="ru"><p>Мастодиния является частым клиническим симптомом в общей врачебной и гинекологической практике. Задачи данного библиографического обзора: провести анализ научных сведений об эпидемиологии мастодинии/масталгии, о влиянии на качество жизни, противоречиях в определении этиологии, сформулировать диагностическую концепцию, классификацию, лечение, а также выяснить терапевтические эффекты Vitex Agnus-Castus. Проведен поиск научных публикаций в основных исследовательских базах данных, CochraneLibrary, PubMed, Science Direct, Google Scholar, ELibrary за последние 30 лет; использованы термины «масталгия/mastalgia», «мастодиния/mastodynia», «прутняк/Vitex Agnus-Castus», «боль в груди», «боль в молочных железах/chest pain, breast pain». Патофизиология мастодинии объясняется не одним механизмом, а разными причинами с независимыми путями формирования болезненных ощущений. Большинство исследований подчеркнули важность правильной классификации боли в молочных железах для точной диагностики и эффективной терапии, чтобы уменьшить частоту и выраженность эпизодов боли и улучшить качество жизни при минимизации побочных эффектов. Препараты на основе Vitex Agnus-Castus являются безопасными и эффективными в лечения мастодинии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>mastalgia</kwd><kwd>mastodynia</kwd><kwd>Vitex Agnus-Castus</kwd><kwd>chest pain</kwd><kwd>breast pain</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>масталгия</kwd><kwd>мастодиния</kwd><kwd>Vitex Agnus-Castus</kwd><kwd>боль в груди</kwd><kwd>боль в молочных железах</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Olawaiye A, Withiam-Leitch M, Danakas G, Kahn K. Mastalgia: a review of management. 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