<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">627141</article-id><article-id pub-id-type="doi">10.26442/20795696.2023.4.202520</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Metabesity: pathogenetic bases and predictive capabilities. A review</article-title><trans-title-group xml:lang="ru"><trans-title>Metabesity – патогенетические основы и возможности предикции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5342-8129</contrib-id><name-alternatives><name xml:lang="en"><surname>Orazov</surname><given-names>Mekan R.</given-names></name><name xml:lang="ru"><surname>Оразов</surname><given-names>Мекан Рахимбердыевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>доктор мед. наук, проф. каф. акушерства и гинекологии с курсом перинатологии Медицинского института</p></bio><email>omekan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4956-0466</contrib-id><name-alternatives><name xml:lang="en"><surname>Radzinsky</surname><given-names>Viktor E.</given-names></name><name xml:lang="ru"><surname>Радзинский</surname><given-names>Виктор Евсеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof., Corr. Memb. RAS</p></bio><bio xml:lang="ru"><p>чл.-кор. РАН, доктор медицины наук, проф., зав. каф. акушерства и гинекологии с курсом перинатологии Медицинского института ФГАОУ ВО РУДН, засл. деятель науки РФ</p></bio><email>radzinsky@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1940-4534</contrib-id><name-alternatives><name xml:lang="en"><surname>Khamoshina</surname><given-names>Marina B.</given-names></name><name xml:lang="ru"><surname>Хамошина</surname><given-names>Марина Борисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>доктор медицины наук, проф., проф. каф. акушерства, гинекологии и репродуктивной медицины Медицинского института</p></bio><email>khamoshina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6709-5209</contrib-id><name-alternatives><name xml:lang="en"><surname>Dolgov</surname><given-names>Evgeny D.</given-names></name><name xml:lang="ru"><surname>Долгов</surname><given-names>Евгений Денисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinical Resident</p></bio><bio xml:lang="ru"><p>клин. ординатор каф. акушерства и гинекологии с курсом перинатологии Медицинского института</p></bio><email>1586dolgde@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5773-6399</contrib-id><name-alternatives><name xml:lang="en"><surname>Mullina</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Муллина</surname><given-names>Ирина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант каф. акушерства, гинекологии и репродуктивной медицины Медицинского института</p></bio><email>211irina2111@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2116-1420</contrib-id><name-alternatives><name xml:lang="en"><surname>Artemenko</surname><given-names>Yulia S.</given-names></name><name xml:lang="ru"><surname>Артеменко</surname><given-names>Юлия Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант каф. акушерства и гинекологии с курсом перинатологии Медицинского института</p> <p> </p></bio><email>omekan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4292-6728</contrib-id><name-alternatives><name xml:lang="en"><surname>Ryabova</surname><given-names>Valentina A.</given-names></name><name xml:lang="ru"><surname>Рябова</surname><given-names>Валентина Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant</p> <p/></bio><bio xml:lang="ru"><p>ассистент каф. акушерства, гинекологии и репродуктивной медицины Медицинского института</p> <p/></bio><email>mikhe-valentina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">People’s Friendship University of Russia (RUDN University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-20" publication-format="electronic"><day>20</day><month>12</month><year>2023</year></pub-date><volume>25</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>416</fpage><lpage>423</lpage><history><date date-type="received" iso-8601-date="2024-02-18"><day>18</day><month>02</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-02-18"><day>18</day><month>02</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/627141">https://gynecology.orscience.ru/2079-5831/article/view/627141</self-uri><abstract xml:lang="en"><p>One of the most pressing problems of our time is obesity, recognized by the WHO as a pandemic of the XXI century. It is important to remember that obesity is a full-fledged nosological entity, but many women think that obesity is just a problem of beauty and aesthetics. It is important to note that this nosology has a number of serious consequences, starting with the development of cardiovascular disease and ending with cancer. However, the “problem in the problem” is the so-called “metabesity” – a new term that reflects a number of diseases, the pathogenesis of which is based on the metabolic syndrome. Obesity, metabolic syndrome and metabesity seem to be different concepts, but the absolute identity of the pathogenetic basis characterizes them as successive stages of one global process. In this regard, it is necessary to highlight the key mechanisms of the development of the described disorders and to consider the concept of clinical management of patients in this cohort.</p></abstract><trans-abstract xml:lang="ru"><p>Одной из самых актуальных проблем современности является ожирение, признанное Всемирной организацией здравоохранения пандемией XXI века. Важно помнить, что ожирение является полноценной нозологической единицей, однако многие женщины полагают, что ожирение – лишь проблема красоты и эстетики. Необходимо отметить, что данная нозология влечет за собой ряд грозных последствий: начиная с развития сердечно-сосудистых заболеваний и заканчивая онкологическими. Однако «проблемой в проблеме» является так называемый metabesity – новый термин, отображающий целый ряд заболеваний, в основе патогенеза которых лежит метаболический синдром. Ожирение, метаболический синдром и metabesity – вроде бы разные понятия, однако абсолютная идентичность патогенетической основы характеризует их как последовательные стадии одного глобального процесса. В этой связи освещены ключевые механизмы развития описанных нарушений и рассмотрена концепция клинического менеджмента пациенток данной когорты.</p></trans-abstract><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>arterial hypertension</kwd><kwd>insulin resistance</kwd><kwd>metabesity</kwd><kwd>peptide therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>артериальная гипертония</kwd><kwd>инсулинорезистентность</kwd><kwd>metabesity</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>World health organization, 2022.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>WHO. Obesity and overweight. Available at: https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight. Accessed: 15.03.2023.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Успенский Ю.П., Петренко Ю.В., Гулунов З.Х., и др. Метаболический синдром. Учебное пособие. СПб. 2017 [Uspenskii IuP, Petrenko IuV, Gulunov ZKh, et al. Metabolicheskii sindrom. Uchebnoie posobiye. Saint Petersburg. 2017 (in Russian)].</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Fasshauer M, Blüher M. Adipokines in health and disease. Trends in Pharmacological Sciences. 2015;36(7):461-70.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clinical Chemistry. 2004;50(9):1511-25.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hetemäki N, Mikkola TS, Tikkanen MJ, et al. Adipose tissue estrogen production and metabolism in premenopausal women. The Journal of Steroid Biochemistry and Molecular Biology. 2021;209:105849.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Радзинский В., Хамошина М., Раевская О., и др. Очерки по эндокринной гинекологии. От синдрома к диагнозу и выбору терапии. М. 2020 [Radzinskii V, Khamoshina M, Rayevskaya O, et al. Ocherki po endokrinnoi ginekologii. Ot sindroma k diagnozu i vyboru terapii. Moscow. 2020 (in Russian)].</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Mazon JN, de Mello AH, Ferreira GK, Rezin GT. The impact of obesity on neurodegenerative diseases. Life Sciences. 2017;182:22-8.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Fan YC, Chou CC, You SL, et al. Impact of worsened metabolic syndrome on the risk of dementia: a nationwide cohort study. J Am Heart Assoc. 2017;6(9):e004749. DOI:10.1161/JAHA.116.004749</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85-97.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kahn CR, Wang G, Lee KY. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J Clin Investig. 2019;129(10):3990-4000.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Feinstein R, Kanety H, Papa MZ, et al. Tumor necrosis factor-α suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993;268(35):26055-8.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lee YS, Li P, Huh JY, et al. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011;60(10):2474-83.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Fahed G, Aoun L, Bou Zerdan M, et al. Metabolic syndrome: Updates on pathophysiology and management in 2021. Int J Mol Sci. 2022;23(2):786.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. 2019;92:121-35.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Оразов М.Р., Радзинский В.Е., Хамошина М.Б., и др. Metabesity у женщин: долгосрочные последствия для здоровья. Доктор.Ру. 2023;22(1):11-5 [Orazov MR, Radzinsky VE, Khamoshina MB, et al. Metabesity in women: long-term health effects. Doctor.Ru. 2023;22(1):11-5 (in Russian)]. DOI:10.31550/1727-2378-2023-22-1-11-15</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Global Cancer Observatory. Available at: https://gco.iarc.fr. Accessed: 15.03.2023.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Tahergorabi Z, Khazaei M, Moodi M, Chamani E. From obesity to cancer: a review on proposed mechanisms. Cell Biochemistry and Function. 2016;34(8):533-45.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Raza SA, Mirza AMB, Hafizullah M, et al. Metabesity guideline: a pakistan perspective. Journal of the Pakistan Medical Association. 2021;71(5):S17-33.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Мироненко А.Ю., Шаргакшанова И.З., Крохмаль Е.В., и др. Индекс инсулинорезистентности в диагностике гестационного сахарного диабета. Медицина завтрашнего дня. 2017:159-60 [Mironenko AIu, Shargakshanova IZ, Krokhmal' EV, et al. Indeks insulinorezistentnosti v diagnostike gestatsionnogo sakharnogo diabeta. Meditsina zavtrashnego dnia. 2017:159-60 (in Russian)].</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Мадянов И.В. Косвенные способы оценки инсулинорезистентности при метаболическом синдроме. РМЖ. 2021;2:10-2 [Madyanov IV. Indirect methods for assessing insulin resistance in metabolic syndrome. RMJ. 2021;2:10-2 (in Russian)].</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>National Institute for Health and Care Excellence: «Obesity: identification, assessment and management». 2022.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Di Vincenzo O, Marra M, Sacco AM, et al. Bioelectrical impedance (BIA)-derived phase angle in adults with obesity: A systematic review. Clin Nutr. 2021;40(9):5238-48.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2010;375(9710):181-3.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Шпилевская Ю.Р., Штонда М.В. Метаболический синдром: современные аспекты диагностики и лечения. Медицинские новости. 2021;5(320) [Shpilevskaya IuR, Shtonda MV. Metabolicheskii sindrom: sovremennyie aspekty diagnostiki i lecheniia. Meditsinskiie novosti. 2021;5(320) (in Russian)].</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>le Roux CW, Astrup A, Fujioka K, et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017;8:1399-409. DOI:10.1016/S0140-6736(17)30069-7</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Wilding JPH. STEP 1+2: signifikante Gewichtsreduktion unter Semaglutid vs. Placebo. J Med. 2021;384:989-1002.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Krome S. STEP 4: langfristig abnehmen mit Semaglutid. Diabetologie und Stoffwechsel. 2021;16(04):256.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Garvey T, Batterham R, Bhatta M, et al. Wirkung von Semaglutid 2, 4 mg vs. Placebo über 2 Jahre bei Erwachsenen mit Adipositas (STEP 5)(#7). Adipositas-Ursachen, Folgeerkrankungen, Therapie. 2022;16(03):V-06.</mixed-citation></ref></ref-list></back></article>
