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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">643240</article-id><article-id pub-id-type="doi">10.26442/20795696.2024.4.203083</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hormonal contraception in women with polycystic ovary syndrome: Contraceptive and non-contraceptive effects. A clinical lecture</article-title><trans-title-group xml:lang="ru"><trans-title>Гормональная контрацепция у женщин с синдромом поликистозных яичников: контрацептивные и неконтрацептивные эффекты. Клиническая лекция</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6117-7270</contrib-id><name-alternatives><name xml:lang="en"><surname>Pustotina</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Пустотина</surname><given-names>Ольга Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. акушерства и гинекологии с курсом репродуктивной медицины</p></bio><email>pustotina@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Inozemtsev Academy of Medical Education</institution></aff><aff><institution xml:lang="ru">ЧОУ ДПО «Академия медицинского образования им. Ф.И. Иноземцева»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-12-27" publication-format="electronic"><day>27</day><month>12</month><year>2024</year></pub-date><volume>26</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>311</fpage><lpage>317</lpage><history><date date-type="received" iso-8601-date="2024-12-20"><day>20</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-12-20"><day>20</day><month>12</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/643240">https://gynecology.orscience.ru/2079-5831/article/view/643240</self-uri><abstract xml:lang="en"><p>The clinical diversity of polycystic ovary syndrome (PCOS) makes the diagnosis challenging, leaving many women untreated. The article deals in detail with the PCOS diagnosis algorithm and pathogenesis, as well as the adverse impact of PCOS on the reproductive and overall health of women. The necessity of using combined hormonal contraception both to prevent unwanted pregnancy and to reduce the risks associated with PCOS is justified, and the advantages of a chlormadinone-containing combined oral contraceptive in women with hyperandrogenism are given.</p></abstract><trans-abstract xml:lang="ru"><p>Клиническое разнообразие синдрома поликистозных яичников (СПЯ) вызывает значительные трудности в диагностике заболевания, вследствие чего многие женщины остаются без лечения. В статье детально разбираются алгоритм диагностики и патогенез СПЯ, а также негативное влияние СПЯ на репродуктивное и общее здоровье женщин. Обосновывается необходимость применения комбинированной гормональной контрацепции как для предотвращения нежелательной беременности, так и для снижения рисков, ассоциированных с СПЯ, а также приводятся преимущества назначения хлормадинонсодержащего комбинированного орального контрацептива у женщин с гиперандрогенией.</p></trans-abstract><kwd-group xml:lang="en"><kwd>insulin resistance</kwd><kwd>hyperandrogenism</kwd><kwd>polycystic ovary syndrome</kwd><kwd>hormonal contraception</kwd><kwd>chlormadinone acetate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инсулинорезистентность</kwd><kwd>гиперандрогения</kwd><kwd>синдром поликистозных яичников</kwd><kwd>гормональная контрацепция</kwd><kwd>хлормадинона ацетат</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Yu O, Christ JP, Schulze-Rath R, et al. Incidence, prevalence, and trends in polycystic ovary syndrome diagnosis: a United States population-based study from 2006 to 2019. Am J Obstet Gynecol. 2023;229(1):39.e1-9e12. DOI:10.1016/j.ajog.2023.04.010</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Shilpa K, Earlina A, Larysa S. The Clinical Manifestations of Polycystic Ovary Syndrome (PCOS) and The Treatment Options. European Journal of Biology and Medical Science Research. 2023;11:57-91.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Tomlinson JA, Pinkney JH, Evans P, et al. Screening for diabetes and cardiometabolic disease in women with polycystic ovary syndrome. The British Journal of Diabetes &amp;Vascular Disease. 2013;13(3):115-23. DOI:10.1177/1474651413495571</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-49. DOI:10.1210/clinem/dgad463</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7. DOI:10.1093/humrep/deh098</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Christ JP, Cedars MI. Current Guidelines for Diagnosing PCOS. Diagnostics (Basel). 2023;13(6):1113. DOI:10.3390/diagnostics13061113</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Fischer-Holzhausen S, Röblitz S. Hormonal regulation of ovarian follicle growth in humans: Model-based exploration of cycle variability and parameter sensitivities. J Theor Biol. 2022;547:111150. DOI:10.1016/j.jtbi.2022.111150</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>De Leo V, Musacchio MC, Cappelli V, et al. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016;14(1):38. DOI:10.1186/s12958-016-0173-x</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Wawrzkiewicz-Jałowiecka A, Kowalczyk K, Trybek P, et al. In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond. Int J Mol Sci. 2020;21(19):7054. DOI:10.3390/ijms21197054</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Lie Fong S, Laven JSE, Duhamel A, Dewailly D. Polycystic ovarian morphology and the diagnosis of polycystic ovary syndrome: redefining threshold levels for follicle count and serum anti-Müllerian hormone using cluster analysis. Hum Reprod. 2017;32(8):1723-71. DOI:10.1093/humrep/dex226</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Silva MSB, Giacobini P. New insights into anti-Müllerian hormone role in the hypothalamic-pituitary-gonadal axis and neuroendocrine development. Cell Mol Life Sci. 2021;78(1):1-6. DOI:10.1007/s00018-020-03576-x</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Niethammer B, Körner C, Schmidmayr M, et al. Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles. Geburtshilfe Frauenheilkd. 2015;75(12):1250-7. DOI:10.1055/s-0035-1558298</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Norman RJ, Morman R, Teede HJ. "Tis but thy name that is my enemy"–the problem with the naming of polycystic ovary syndrome. Fertil Steril. 2023;120(2):249-50. DOI:10.1016/j.fertnstert.2023.03.028</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Tosi F, Bonora E, Moghetti P. Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes. Hum Reprod. 2017;32(12):2515-51. DOI:10.1093/humrep/dex308</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Cassar S, Misso ML, Hopkins WG, et al. Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies. Hum Reprod. 2016;31(11):2619-61. DOI:10.1093/humrep/dew243</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lim SS, Davies MJ, Norman RJ, Moran LJ. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(6):618-37. DOI:10.1093/humupd/dms030</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ovalle F, Azziz R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril. 2002;77(6):1095-105. DOI:10.1016/s0015-0282(02)03111-4</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Unluhizarci K, Karaca Z, Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes. 2021;12(5):616-29. DOI:10.4239/wjd.v12.i5.616</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Joham AE, Norman RJ, Stener-Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668-80. DOI:10.1016/S2213-8587(22)00163-2</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Carlomagno G, Unfer V, Roseff S. The D-chiro-inositol paradox in the ovary. Fertil Steril. 2011;95(8):2515-6. DOI:10.1016/j.fertnstert.2011.05.027</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Diamanti-Kandarakis E, Papalou O, Kandaraki EA. The Role of Androgen Excess on Insulin Sensitivity in Women. Front Horm Res. 2019;53:50-64. DOI:10.1159/000494902</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Tuorila K, Ollila MM, Järvelin MR, et al. Hyperandrogenemia in Early Adulthood Is an Independent Risk Factor for Abnormal Glucose Metabolism in Middle Age. J Clin Endocrinol Metab. 2021;106(11):e4621-33. DOI:10.1210/clinem/dgab456</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Пустотина О.А., Расулова И.А. Влияние миоинозитола и Д-хироинозитола в соотношении 40:1 на гормональные и метаболические показатели у женщин с синдромом поликистозных яичников. Акушерство и гинекология. 2023;9:146-54 [Pustotina OA, Rasulova IA. Vliianie mioinozitola i D-khiroinozitola v sootnoshenii 40:1 na gormonal'nye i metabolicheskie pokazateli u zhenshchin s sindromom polikistoznykh iaichnikov. Akusherstvo i ginekologiia. 2023;9:146-54 (in Russian)].</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Unfer V, Dinicola S, Russo M. A PCOS Paradox: Does Inositol Therapy Find a Rationale in All the Different Phenotypes? Int J Mol Sci. 2023;24(7). DOI:10.3390/ijms24076213</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Alviggi C, Conforti A, De Rosa P, et al. The Distribution of Stroma and Antral Follicles Differs between Insulin-Resistance and Hyperandrogenism-Related Polycystic Ovarian Syndrome. Front Endocrinol (Lausanne). 2017;8:117. DOI:10.3389/fendo.2017.00117</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Genazzani AD, Genazzani AR. Polycystic Ovary Syndrome as Metabolic Disease: New Insights on Insulin Resistance. touchREV Endocrinol. 2023;19(1):71-7. DOI:10.17925/EE.2023.19.1.71</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Palomba S, Piltonen TT, Giudice LC. Endometrial function in women with polycystic ovary syndrome: a comprehensive review. Hum Reprod Update. 2021;27(3):584-618. DOI:10.1093/humupd/dmaa051</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Moghetti P, Tosi F, Bonin C, et al. Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome. J Clin Endocrinol Metab. 2013;98(4):E628-37. DOI:10.1210/jc.2012-3908</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Dai S, Zhang H, Yang F, et al. Effects of IGF-1 on the Three-Dimensional Culture of Ovarian Preantral Follicles and Superovulation Rates in Mice. Biology (Basel). 2022;11(6). DOI:10.3390/biology11060833</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Young CH, Snow B, DeVore SB, et al. Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells. Reproduction. 2021;162(2):117-27. DOI:10.1530/REP-21-0132</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Пустотина О.А. Фенотипы синдрома поликистозных яичников. Фарматека. 2023;30(4-5):156-63 [Pustotina OA. Polycystic ovary syndrome phenotypes. Pharmateca. 2023;30(4-5):156-63 (in Russian)]. DOI:10.18565/pharmateca.2023.4-5.156-163</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>WHO/SRH and Johns Hopkins Bloomberg School of Public Health/Center for Communication Programs (CCP), Knowledge SUCCESS. Family Planning: A Global Handbook for Providers (2022 update). Baltimore and Geneva: CCP and WHO, 2022.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Национальные медицинские критерии приемлемости методов контрацепции (Адаптированный документ «Медицинские критерии приемлемости использования методов контрацепции ВОЗ, 5-е издание, 2015»). М. 2023 [Natsional'nye meditsinskie kriterii priemlemosti metodov kontratseptsii (Adaptirovannyi dokument «Meditsinskie kriterii priemlemosti ispol'zovaniia metodov kontratseptsii VOZ, 5-e izdanie, 2015»). Moscow. 2023 (in Russian)].</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Family Planing: A global handbook for providers. Update 4th еdition. 2022. Available at: www.fphandbook.org. Accessed: 15.08.2024.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Schrager S, Larson M, Carlson J, et al. Beyond Birth Control: Noncontraceptive Benefits of Hormonal Methods and Their Key Role in the General Medical Care of Women. J Womens Health (Larchmt). 2020;29(7):937-43. DOI:10.1089/jwh.2019.7731</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Naessén S, Carlström K, Byström B, et al. Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women. Psychoneuroendocrinology. 2007;32(5):548-4. DOI:10.1016/j.psyneuen.2007.03.008</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Honma S, Iwamura S, Iizuka K, et al. Identification and anti-androgenic activity of the metabolites of 17alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione (chlormadinone acetate) in the rat, rabbit, dog and man. Chem Pharm Bull (Tokyo). 1977;25(8):2019-31. DOI:10.1248/cpb.25.2019</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Пеcтрикова Т.Ю., Юрасова Е.А., Никоноркина И.Ю. Оценка лечебных эффектов и влияния на сексуальную активность препарата Белара. Гинекология. 2015;17(3):88-92 [Pestrikova TYu, Yurasova EA., Nikonorkina IYu. Evaluation of therapeutic effects and impact on the sexual activity of Belara. Gynecology. 2015;17(3):88-92 (in Russian)].</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Huber JC, Heskamp ML, Schramm GA. Effect of an oral contraceptive with chlormadinone acetate on depressive mood: analysis of data from four observational studies. Clin Drug Investig. 2008;28(12):783-91. DOI:10.2165/0044011-200828120-00006</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Contreras CM, Azamar-Arizmendi G, Saavedra M, Hernández-Lozano M. A five-day gradual reduction regimen of chlormadinone reduces premenstrual anxiety and depression: a pilot study. Arch Med Res. 2006;37(7):907-13. DOI:10.1016/j.arcmed.2006.05.001</mixed-citation></ref></ref-list></back></article>
