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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">685378</article-id><article-id pub-id-type="doi">10.26442/20795696.2026.1.203564</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Medical ozone for the treatment of certain cervical diseases: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Применение медицинского озона в лечении некоторых заболеваний шейки матки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5256-843X</contrib-id><name-alternatives><name xml:lang="en"><surname>Zaynetdinova</surname><given-names>Larisa F.</given-names></name><name xml:lang="ru"><surname>Зайнетдинова</surname><given-names>Лариса Фоатовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Assoc. Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доц., проф. каф. акушерства и гинекологии</p></bio><email>sea-gull6@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7884-9675</contrib-id><name-alternatives><name xml:lang="en"><surname>Telesheva</surname><given-names>Larisa F.</given-names></name><name xml:lang="ru"><surname>Телешева</surname><given-names>Лариса Федоровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., проф. каф. микробиологии, вирусологии и иммунологии</p></bio><email>sea-gull6@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Privalova</surname><given-names>Evgeniya E.</given-names></name><name xml:lang="ru"><surname>Привалова</surname><given-names>Евгения Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, врач – акушер-гинеколог, репродуктолог, глав. врач</p></bio><email>sea-gull6@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khakulina</surname><given-names>Victoria V.</given-names></name><name xml:lang="ru"><surname>Хахулина</surname><given-names>Виктория Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Obst./Gyn.</p></bio><bio xml:lang="ru"><p>врач – акушер-гинеколог</p></bio><email>sea-gull6@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">South Ural State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Family Medicine Center</institution></aff><aff><institution xml:lang="ru">АО «Центр семейной медицины»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-03-10" publication-format="electronic"><day>10</day><month>03</month><year>2026</year></pub-date><volume>28</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>55</fpage><lpage>59</lpage><history><date date-type="received" iso-8601-date="2025-06-20"><day>20</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/685378">https://gynecology.orscience.ru/2079-5831/article/view/685378</self-uri><abstract xml:lang="en"><p>The mixture of ozone and oxygen (O<sub>3</sub>–O<sub>2</sub>, 5:95) is called "medical ozone." Ozone therapy, which uses an ozone-oxygen mixture, is applied for a wide range of diseases, including certain cervical diseases. It is also used in other branches of medicine, such as the treatment of purulent wounds, inflammatory-degenerative diseases, and circulatory disorders. In cervical diseases, low concentrations of ozone used therapeutically do not cause toxic effects and exhibit immunomodulatory, anti-inflammatory, bactericidal, antiviral, fungicidal, antihypoxic, reparative, and related effects. Ozone therapy has shown efficacy in the treatment of benign cervical diseases, including those associated with HPV, which justifies its further research. For severe dysplasia, ozone therapy may be considered an adjunctive method of rehabilitation, rather than a substitute for surgical treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Смесь озона с кислородом (О<sub>3</sub>–О<sub>2</sub>) в соотношении 5% озона и 95% кислорода получила название «медицинский озон». Озонотерапия – это использование озоно-кислородной смеси в лечении широкого спектра заболеваний. В настоящее время она нашла применение в различных отраслях медицины, особенно при лечении гнойных ран, воспалительно-дегенеративных заболеваний, расстройств кровообращения. Низкие концентрации озона, применяемые с лечебной целью, не вызывают развития токсических эффектов. В этом случае озон способен оказывать иммуномодулирующий, противовоспалительный, бактерицидный, противовирусный, фунгицидный, антигипоксический, репаративный и другие эффекты. Озонотерапия показала эффективность при лечении доброкачественных заболеваний шейки матки, в том числе ассоциированных с ВПЧ, что обосновывает перспективы ее дальнейшего исследования в этой области медицины. В случае тяжелой дисплазии озонотерапия может рассматриваться как вспомогательный метод реабилитации, а не замена хирургического лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cervix uteri</kwd><kwd>medical ozone</kwd><kwd>anti-inflammatory agents</kwd><kwd>antiviral agents</kwd><kwd>diseases of the cervix uteri</kwd><kwd>human papillomavirus viruses</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>шейка матки</kwd><kwd>медицинский озон</kwd><kwd>противовоспалительные средства</kwd><kwd>противовирусные средства</kwd><kwd>заболевания шейки матки</kwd><kwd>вирусы папилломы человека</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Smith NL, Wilson AL, Jason Gandhi J, et al. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Medical Gas Res. 2017;7(3):212-9. 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