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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">690196</article-id><article-id pub-id-type="doi">10.26442/20795696.2026.1.203435</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Allergic reactions of the lower genital tract in women: diagnosis, therapy, prevention, and long-term follow-up strategies. A review</article-title><trans-title-group xml:lang="ru"><trans-title>Аллергические реакции нижних отделов половых путей у женщин: диагностика, терапия, профилактика и стратегии долгосрочного наблюдения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2977-9065</contrib-id><name-alternatives><name xml:lang="en"><surname>Mezhevitinova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Межевитинова</surname><given-names>Елена Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, вед. науч. сотр. научно-поликлинического отд-ния</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3993-7629</contrib-id><name-alternatives><name xml:lang="en"><surname>Prilepskaya</surname><given-names>Vera N.</given-names></name><name xml:lang="ru"><surname>Прилепская</surname><given-names>Вера Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. научно-поликлиническим отд-нием, заслуженный деятель науки РФ</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6907-2817</contrib-id><name-alternatives><name xml:lang="en"><surname>Bychkova</surname><given-names>Natalia V.</given-names></name><name xml:lang="ru"><surname>Бычкова</surname><given-names>Наталья Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Biol.)</p></bio><bio xml:lang="ru"><p>д-р биол. наук, вед. науч. сотр. лаб. клинической иммунологии</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5023-3476</contrib-id><name-alternatives><name xml:lang="en"><surname>Krechetova</surname><given-names>Liubov V.</given-names></name><name xml:lang="ru"><surname>Кречетова</surname><given-names>Любовь Валентиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, зав. лаб. клинической иммунологии</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4201-1360</contrib-id><name-alternatives><name xml:lang="en"><surname>Kepsha</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Кепша</surname><given-names>Мария Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Jun. Res.</p></bio><bio xml:lang="ru"><p>мл. науч. сотр., врач научно-поликлинического отд-ния</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0574-1230</contrib-id><name-alternatives><name xml:lang="en"><surname>Mgeryan</surname><given-names>Anna N.</given-names></name><name xml:lang="ru"><surname>Мгерян</surname><given-names>Анна Нерсесовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ст. науч. сотр. научно-поликлинического отд-ния</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2679-4991</contrib-id><name-alternatives><name xml:lang="en"><surname>Strokova</surname><given-names>Svetlana O.</given-names></name><name xml:lang="ru"><surname>Строкова</surname><given-names>Светлана Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Clinical Laboratory Diagnostics Physician</p></bio><bio xml:lang="ru"><p>врач клинической лабораторной диагностики лаб. по сбору и хранению биоматериалов</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3504-2406</contrib-id><name-alternatives><name xml:lang="en"><surname>Donnikov</surname><given-names>Andrey E.</given-names></name><name xml:lang="ru"><surname>Донников</surname><given-names>Андрей Евгеньевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, зав. лаб. молекулярно-генетических методов</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2835-6685</contrib-id><name-alternatives><name xml:lang="en"><surname>Dovletkhanova</surname><given-names>Elmira R.</given-names></name><name xml:lang="ru"><surname>Довлетханова</surname><given-names>Эльмира Робертовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ст. науч. сотр. научно-поликлинического отд-ния</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8243-5272</contrib-id><name-alternatives><name xml:lang="en"><surname>Abakarova</surname><given-names>Patimat R.</given-names></name><name xml:lang="ru"><surname>Абакарова</surname><given-names>Патимат Рапиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ст. науч. сотр. научно-поликлинического отд-ния</p></bio><email>mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-03-10" publication-format="electronic"><day>10</day><month>03</month><year>2026</year></pub-date><volume>28</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>34</fpage><lpage>42</lpage><history><date date-type="received" iso-8601-date="2025-09-08"><day>08</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/690196">https://gynecology.orscience.ru/2079-5831/article/view/690196</self-uri><abstract xml:lang="en"><p>Allergic reactions of the lower genital tract in women cause significant chronic vulvovaginal discomfort and require active diagnosis and treatment. Modern approaches to therapy, which combine allergen elimination and anti-inflammatory therapy, can achieve improvement or cure in most cases. Obstetricians-gynecologists are recommended to involve dermatovenerologists and allergists for joint management of patients in case of non-standard cases of vaginitis. From a scientific point of view, further studies of immune mechanisms in the genital tract and the development of new methods of specific therapy and prevention remain relevant. In the future, the results of such studies will help to develop more accurate clinical guidelines and improve the effectiveness of care for these patients. Successful treatment of allergic diseases of the vulva and vagina significantly improves the quality of life, restores a woman's confidence and comfort in everyday and intimate life. Developing an interdisciplinary approach, education, and a thoughtful method for addressing symptoms can help overcome many difficulties in diagnosing and treating this condition. The identified unresolved issues will serve as the starting point for new research and progress in this field of medicine.</p></abstract><trans-abstract xml:lang="ru"><p>Аллергические реакции нижних отделов половых путей у женщин – значимая причина хронического вульвовагинального дискомфорта, которую следует активно выявлять и лечить. Современные подходы терапии, основанные на комбинации элиминации аллергенов и противовоспалительной терапии, в большинстве случаев позволяют добиться улучшения или излечения. Практическим врачам – акушерам-гинекологам рекомендуется при нестандартных случаях вагинита привлекать дерматовенерологов и аллергологов для совместного ведения пациенток. С научной точки зрения остаются актуальными дальнейшие исследования иммунных механизмов на уровне генитального тракта, разработка новых методов специфической терапии и профилактики. В перспективе результаты таких исследований помогут создать более точные клинические рекомендации и повысить эффективность помощи этим пациенткам. Успешное лечение аллергических заболеваний вульвы и влагалища значительно улучшает качество жизни, возвращая женщине уверенность и комфорт в повседневной и интимной сфере. Развитие междисциплинарного подхода, просвещение и внимательное отношение к жалобам помогут преодолеть многие трудности в диагностике и терапии такой патологии, а выявленные нерешенные вопросы станут отправной точкой для новых исследований и прогресса в этой области медицины.</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergic reactions of the lower genital tract in women</kwd><kwd>allergic diseases of the anogenital region in women</kwd><kwd>itching of the vulva</kwd><kwd>contact dermatitis</kwd><kwd>delayed-type hypersensitivity</kwd><kwd>patch testing</kwd><kwd>vulvovaginal discomfort</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллергические реакции нижних отделов половых путей у женщин</kwd><kwd>аллергические заболевания аногенитальной области у женщин</kwd><kwd>зуд вульвы</kwd><kwd>контактный дерматит</kwd><kwd>гиперчувствительность замедленного типа</kwd><kwd>патч-тестирование</kwd><kwd>вульвовагинальный дискомфорт</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Woelber L, Prieske K, Mendling W, et al. 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