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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-5696</issn><issn publication-format="electronic">2079-5831</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">690268</article-id><article-id pub-id-type="doi">10.26442/20795696.2025.4.203490</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Innovations in the diagnosis and treatment of endometriosis: from the current advancements to a future outlook: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Инновации в диагностике и терапии эндометриоза: от достижений настоящего к прогрессивному взгляду в будущее</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5342-8129</contrib-id><name-alternatives><name xml:lang="en"><surname>Orazov</surname><given-names>Mekan R.</given-names></name><name xml:lang="ru"><surname>Оразов</surname><given-names>Мекан Рахимбердыевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. акушерства и гинекологии с курсом перинатологии Медицинского института</p></bio><email>omekan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4956-0466</contrib-id><name-alternatives><name xml:lang="en"><surname>Radzinsky</surname><given-names>Viktor E.</given-names></name><name xml:lang="ru"><surname>Радзинский</surname><given-names>Виктор Евсеевич</given-names></name></name-alternatives><address><country country="RW">Rwanda</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof., Acad. RAS</p></bio><bio xml:lang="ru"><p>акад. РАН, д-р мед. наук, проф., зав. каф. акушерства и гинекологии с курсом перинатологии Медицинского института, засл. деят. науки РФ</p></bio><email>omekan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6709-5209</contrib-id><name-alternatives><name xml:lang="en"><surname>Dolgov</surname><given-names>Evgeny D.</given-names></name><name xml:lang="ru"><surname>Долгов</surname><given-names>Евгений Денисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinical Resident</p></bio><bio xml:lang="ru"><p>клинический ординатор каф. акушерства и гинекологии с курсом перинатологии Медицинского института</p></bio><email>omekan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples' Friendship University of Russia named after Patrice Lumumba</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2025</year></pub-date><volume>27</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>281</fpage><lpage>286</lpage><history><date date-type="received" iso-8601-date="2025-09-10"><day>10</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://gynecology.orscience.ru/2079-5831/article/view/690268">https://gynecology.orscience.ru/2079-5831/article/view/690268</self-uri><abstract xml:lang="en"><p>The search for approaches to diagnosing and treating endometriosis remains a priority in modern gynecology. The extremely high prevalence of this condition and its detrimental effect on somatic and reproductive health and the quality of life of patients determine the need for long-term therapy. The article describes evidence-based, modern guidelines-regulated approaches to the clinical management of patients with endometriosis. Currently, the arsenal of a modern clinician includes several technologies for effective clinical management of such patients (pain management, infertility treatment, monitoring the progression and recurrence of the disease, and quality of life). One such approach is the use of the “gold standard” pharmacotherapy for endometriosis with progestogens, namely dienogest 2 mg, which has been proven not only to relieve symptoms but also to effectively control endometriosis progression and recurrence. The immediate and long-term prospects for the diagnosis and treatment of endometriosis, in particular, drugs with an anti-angiogenic mechanism of action that can potentially change the prognosis of patients with this disease, are also considered.</p></abstract><trans-abstract xml:lang="ru"><p>Поиск современных подходов к диагностике и лечению эндометриоза остается одним из приоритетных вопросов современной гинекологии. Чрезвычайно высокие показатели распространенности данного заболевания, его пагубное влияние на соматическое и репродуктивное здоровье, а также качество жизни пациенток определяют необходимость долгосрочной терапии. В статье отражены доказанные и регламентированные современными гайдлайнами подходы к клиническому менеджменту пациенток, страдающих эндометриозом. В настоящее время в арсенале современного клинициста имеется ряд доказанных технологий для эффективного клинического менеджмента (купирования болевого синдрома, преодоления бесплодия, контроля прогрессирования и рецидивов болезни и качества жизни) пациенток данной когорты. Одна из таких технологий – использование «золотого стандарта» фармакотерапии эндометриоза прогестагенов, а именно диеногеста 2 мг, не только доказанно купирующего симптомы, но и эффективно контролирующего его прогрессирующее и рецидивирующее течение. Рассмотрены также ближайшие и отдаленные перспективы диагностики и лечения эндометриоза, в частности препаратов с с антиангиогенным механизмом действия, потенциально способных изменить прогноз пациенток с этим заболеванием.</p></trans-abstract><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>dienogest</kwd><kwd>innovative treatment</kwd><kwd>real-world practice</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>диеногест</kwd><kwd>инновационное лечение</kwd><kwd>реальная клиническая практика</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The paper was prepared with the financial support of the company Gedeon Richter</funding-statement><funding-statement xml:lang="ru">Материал подготовлен при финансовой поддержке компании «Гедеон Рихтер»</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Zondervan KT, Becker CM, Missmer SA. Endometriosis. 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