GynecologyGynecologyГинекология2079-56962079-5831Consilium Medicum7101110.26442/20795696.2021.2.200742REVIEWОБЗОРReview ArticleHuman papillomavirus vaccination: evidence base for efficacy and safetyВакцинация от вируса папилломы человека: доказательная база эффективности и безопасностиhttps://orcid.org/0000-0003-2786-6181DobrokhotovaYuliya E.ДоброхотоваЮлия Эдуардовна
Russian Federation

D. Sci. (Med.), Prof., Pirogov Russian National Research Medical University

д-р мед. наук, проф., засл. врач РФ, зав. каф. акушерства и гинекологии лечебного фак-та ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

pr.dobrohotova@mail.ruhttps://orcid.org/0000-0001-7140-262X8897-8605BorovkovaEkaterina I.БоровковаЕкатерина Игоревна
Russian Federation

D. Sci. (Med.), Assoc. Prof., Pirogov Russian National Research Medical University

д-р мед. наук, доц., проф. каф. акушерства и гинекологии ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Katyanikitina@mail.ruPirogov Russian National Research Medical UniversityФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России150420212321251302505202125052021Copyright ©; 2021, Consilium MedicumCopyright ©; 2021, ООО "Консилиум Медикум"2021Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://gynecology.orscience.ru/2079-5831/article/view/71011

The article provides a literature review on the prevention of cervical cancer by human papillomavirus (HPV) vaccination. Currently, 3 vaccines are available: the 4-valent vaccine against HPV types 6, 11, 16 and 18, the 9-valent vaccine against HPV types 6, 11, 16, 18, 31, 33, 45, 52, 58 and the bivalent vaccine against HPV types 16 and 18. Vaccination provides protection for women and men against infection with HPV and further development of HPV-associated diseases. Following immunization, seroconversion develops in 93-100% of women and in 99-100% of men and is effective in preventing incident and persistent HPV infection as well as cervical intraepithelial neoplasia. HPV immunization is ineffective in treating an existing HPV infection, genital warts, or anogenital intraepithelial neoplasia. HPV vaccination status does not affect recommendations for cervical cancer screening.

Представлен обзор литературы, посвященный профилактике развития рака шейки матки путем проведения вакцинации от вируса папилломы человека (ВПЧ). В настоящее время внедрены 3 вакцины: 4-валентная вакцина от 6, 11, 16 и 18-го типов ВПЧ, 9-валентная вакцина от 6, 11, 16, 18, 31, 33, 45, 52, 58-го типов и бивалентная вакцина от ВПЧ 16 и 18-го типов. Вакцинация обеспечивает защиту для женщин и мужчин от инфицирования и развития в последующем ВПЧ-ассоциированных заболеваний. После иммунизации сероконверсия развивается у 93–100% женщин и у 99–100% мужчин и эффективна в отношении предотвращения инцидентной и персистирующей ВПЧ-инфекции и развития цервикальной интраэпителиальной неоплазии. Иммунизация против ВПЧ неэффективна для устранения уже имеющейся инфекции ВПЧ, генитальных бородавок или аногенитальной интраэпителиальной неоплазии. Статус вакцинации против ВПЧ не влияет на рекомендации по скринингу рака шейки матки.

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