Development of a panel of biomarkers for differential diagnosis of multiple sclerosis

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One such disease is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum diseases (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1601-644 + PRX451-494 + PTK6301-344 + LMP1285-330) allows us to distinguish MS from ALS (AUC = 0,796) and NMOSD (AUC = 0,779).

Авторлар туралы

L. Ovchinnikova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: yasha.l@bk.ru
Ресей, Moscow

S. Dzhelad

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: yasha.l@bk.ru
Ресей, Moscow

T. Simaniv

Research Center of Neurology

Email: yasha.l@bk.ru
Ресей, Moscow

M. Zakharova

Research Center of Neurology

Email: yasha.l@bk.ru
Ресей, Moscow

Y. Lomakin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Хат алмасуға жауапты Автор.
Email: yasha.l@bk.ru
Ресей, Moscow

A. Gabibov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University

Email: gabibov@gmail.com

Academician of the RAS

Ресей, Moscow; Moscow

S. Illarioshkin

Research Center of Neurology

Email: yasha.l@bk.ru

Academician of the RAS

Ресей, Moscow

Әдебиет тізімі

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