The Action of Dinitrosyl Iron Complexes with a Ligand Based on N-acethyl-L-cysteine upon Inhalation Delivery of These Complexes to Rats

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The objective of the present research was to study the action of dinitrosyl iron complexes (DNIC) with a ligand based on N-acetyl-L-cysteine upon long-term inhalation exposure of rats to this substance. It has been shown that as a result, NO stabilized forms pass efficiently through the alveolal membrane into the lung tissue leading to the accumulation of dinitrosyl iron complexes with protein ligands and to an increase in the total NO level in the lungs and other organs thereby inducing a significant and long-lasting hypotensive effect.

作者简介

A. Timoshin

National Medical Research Center of Cardiology named after academician E.I. Chazov

Email: timoshin_a_a@mail.ru
Moscow, Russia

K. Shumaev

National Medical Research Center of Cardiology named after academician E.I. Chazov; A.N. Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Moscow, Russia

V. Lakomkin

National Medical Research Center of Cardiology named after academician E.I. Chazov

Moscow, Russia

A. Abramov

National Medical Research Center of Cardiology named after academician E.I. Chazov

Moscow, Russia

E. Ruuge

National Medical Research Center of Cardiology named after academician E.I. Chazov; M.V. Lomonosov Moscow State University

Department of Physics Moscow, Russia

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