Contemporary views on morphological changes in internal organs under vibration exposure (literature review)

In the structure of occupational morbidity, the leading position is occupied by diseases caused by the influence of physical factors, a special place is given to vibration effects. In Russia, vibration disease is highly prevalent, leads to loss of ability to work, development of complications, and disability. The pathophysiology and clinical manifestations of the disease are widely described. All functional disorders are based on morphological ones, in connection with which it is important to study the material substrate of vibration disease. Its main manifestation is considered to be damage to the nervous and muscular systems. The purpose of the investigation is to analyze modern studies of the morphological aspects of the impact of vibration on internal organs, which will allow deepening our understanding of the pathogenesis of vibration disease for the purpose of its effective treatment and prevention.The search and selection of sources was carried out using the following databases: Scopus, MedLine, Web of Science, PubMed, Google Scholar, CyberLeninka, and Russian Science Citation Index (RSCI).Conclusion. The review presents an analysis of modern studies of the morphological aspects of the effects of vibration on internal organs, which allows a deeper understanding of the pathogenesis of the disease. Many researchers are shown to note the presence of a destructive effect of vibration on the nervous system in experimental animals during the contact and post-contact periods. The picture of morphological changes in other organs and systems allows confirming the concept of vibration disease as a systemic process, reveals the main mechanisms of damage, which are characterized by a consistent increase in adverse effects, starting with vascular disorders of the microvascular bed and ending with multiple organ pathology with irreversible changes.Contribution: Bugaeva M.S. – study concept, collection of material, writing the text; Gorokhova L.G. – collection of material, writing the text; Yamshchikova A.V. – editing the text; Gostyaeva E.P. – collection of material. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.Conflict of interest. The authors declare no conflict of interest.Acknowledgement. The study had no sponsorship.Received: March 3, 2025 / Revised: March 30, 2025 / Accepted: April 8, 2025 / Published: April 30, 2025

vibration exposure, organ specificity, morphological studies, review