THE INVESTIGATION OF METHOTREXATE BIOLOGICAL EFFECTS ON EXAMPLE OF DROSOPHILA MELANOGASTER

Capa

Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

Results of investigations into some immunobiochemical indices in crucian carp at a chronic exposure to sublethal concentrations of copper ions are reported. Anti- microbial properties in the blood serum and a share of immunodeficient fishes were studied; in liver a content of nonspecific immune complexes, level of common lipids, content of lipid peroxidation products and antioxidant activity were investigated. The dependency of values of indices under consideration on how long fishes stayed under experimental conditions was shown.

Sobre autores

O. Antosyuk

Ural Federal University named after the first President of Russia B.N. Yeltsin

Autor responsável pela correspondência
Email: noemail@neicon.ru
Rússia

A. Marvin

Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: noemail@neicon.ru
Rússia

Bibliografia

  1. Abazykin G., Kondrashov A.S. Major role of positive selection in the evolution of conservative segments of Drosophila proteins. Proc.R.Soc.B.2012; V.279: 3409-17.
  2. Stampfer M.J., Christensen B., Grovannucci E. et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidimeol. Biomarkers Prev. 1999;V.8. (9): 825-29.
  3. Martin F.A., Herrera S.C., Morata G. Cell competition, growth and size control in the Drosophila wing imaginal disc // Development. 2006; V.136. (22): 3747-56.
  4. Kislukhin G., Murphy M.L., Jafari M., Long A.D. Chemotherapy – induced toxicity is highly heritable in Drosophila melanogaster. Pharmacogenet. Genomics. 2012; V. 22.(4): 285-89.
  5. Коваленко Л.В., Захаренко Л.П., Захаров И.К. Транспозиция hobo-элемента в соматических клетках Drosophila melanogaster. Генетика. 2006; Т.42. (2): 177-84.
  6. Антосюк О.Н., Марвин А.М., Марвин Н.А. Сравнительный анализ воздействия цитостатических препаратов на нестабильность генома Drosophila melanogaster. Биомедицина. 2014; (3): 83-91.
  7. Захаренко Л.П., Воложина М.А., Захаров И.К. Влияние генетического окружения на локус-специфичную нестабильность в гене yellow Drosophila melanogaster из Умани. Генетика. 2007; Т. 43. (7): 938-42.
  8. Sheen F., Lim K., Simmons M.J. 1993. Genetic Instability in Drosophila melanogaster Mediated by hobo Transposable Elements. Genetics. 1993; V. 133: 315-34.
  9. Atkinson P.W., Warren W.D., O`Brochta D.A. The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize. Proc. Natl. Acad. Sci. USA. 1993; V. 90.(20): 9693-97.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Antosyuk O.N., Marvin A.M., 2016



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.