Acute poisoning with phenothiazine neuroleptics. Phenothiazine coma

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The article summarizes the authors' long-term experience in the diagnosis and treatment of acute poisoning with phenothiazine derivatives and presents data on the epidemiology of the effects of phenothiazines on the central nervous system. The original classification of acute phenothiazine intoxication confirmed by electrophysiological studies of the brain is given. The involvement of deep brain structures in the pathogenesis of acute phenothiazine coma has been confirmed. Based on studies of visual evoked potentials, the absence of inhibition of deep brain structures despite a pronounced comatose state is shown. In some cases, repeated light stimulation provoked hypersynchronization of evoked potentials and the appearance of convulsive manifestations in the clinic, which was regarded as a state of parabiosis (according to N.E. Vvedensky). Emergency treatment measures for phenothiazine poisoning associated with accelerated detoxification of the body mainly using active methods such as peritoneal dialysis, intestinal lavage with constant monitoring of respiratory function and the cardiovascular system, are presented. The materials of the article will help doctors of intensive care and toxicology departments to improve the quality of diagnosis and treatment of these pathologies.

Sobre autores

V. Alexandrovsky

N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department

Email: vna36@mail.ru
ORCID ID: 0000-0002-0722-239X

Vladimir N. Alexandrovsky.

129090, Moscow.

Rússia

S. Petrikov

N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation

Email: PetrikovSS@sklif.mos.ru
ORCID ID: 0000-0003-3292-8789

Sergei S. Petrikov.

129090, Moscow; 127473, Moscow.

Rússia

M. Kareva

N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation

Autor responsável pela correspondência
Email: Marlex2014@mail.ru
ORCID ID: 0000-0002-6561-843X

Mariya V. Kareva - PhD in Medicine, Head of the Reception Department of the Center for Acute Poisoning for Mental Patients of N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department.

129090, Moscow; 125993, Moscow.

Rússia

Bibliografia

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