Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety Levels and Depressive-like Behavior

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Аннотация

The aim of this study was to investigate the functional role of the TAAR1 receptor, one of the representatives of trace amine-associated receptors (TAARs). The behavior of TAAR1-KO knockout mice and wild-type WT mice were studied in tests reflecting the anxiety and depressive-like conditions. In the Novelty-Suppressed Feeding Test, it was shown that in TAAR1-KO mice the average time to approach the bait was significantly shorter than in WT mice. No statistically significant differences were found for all other parameters of feeding behavior (latency before the start of eating, duration of food consumption, number of approaches with sniffing the bait, number of meals). In the tail suspension test and the Porsolt forced swimming test, the LP of the first immobilization was significantly higher in TAAR1-KO mice. In the Porsolt test, TAAR1-KO mice showed a lower duration of immobilization compared to WT mice.

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Авторлар туралы

E. Vinogradova

Saint Petersburg State University

Хат алмасуға жауапты Автор.
Email: e.vinogradova@spbu.ru
Ресей, St. Petersburg

D. Belyakov

Saint Petersburg State University

Email: e.vinogradova@spbu.ru
Ресей, St. Petersburg

A. Kozyreva

Saint Petersburg State University

Email: e.vinogradova@spbu.ru
Ресей, St. Petersburg

D. Orlova

Saint Petersburg State University

Email: e.vinogradova@spbu.ru
Ресей, St. Petersburg

A. Aleksandrov

Saint Petersburg State University

Email: e.vinogradova@spbu.ru
Ресей, St. Petersburg

Әдебиет тізімі

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2. Fig. 1. Latent periods. (a) - LP of approach to food in the test of suppression of eating behavior in a novel environment. (b) - LP of the first immobilization in the tail suspension test. (c) - LP of the first immobilization in the Porsolt test. Horizontal line - animal groups, vertical line - LP in seconds (c). White bar represents TAAR1-KO mice, dark bar represents WT. * p < 0.05, ** p < 0.01.

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