Oleogels for the Promotion of Healthy Skin Care Products: Synthesis and Characterization of Allantoin Containing Moringa-based Oleogel


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Abstract

Background:Oleogelation is an efficient and emerging approach for obtaining biocompatible and biodegradable elastic semisolid crystals to be used in various cosmetic and pharmaceutical formulations. Recently, drug incorporation in oil structuring has been a promising strategy under consideration due to the effectiveness of this method. Plant oils have very beneficial characteristics for skin care and wound healing due to the presence of certain antioxidants.

Methods:In this study, the oleogels of Moringa oleifera seed oil with natural polysaccharides, including pectin, chitosan, and xanthan gum, were prepared using the emulsion template method. Moringa oil was selected because it can hydrate and moisturize the skin and has great antioxidant activity. Also, the natural polysaccharides, i.e., pectin and chitosan, exhibited good gelling properties. Allantoin, which is a wound healer and eucalyptus leaf oil with antioxidant potential, was incorporated into the emulsion-based-oleogels to enhance the antioxidant and antimicrobial activity of the oleogels.

Results:Allantoin and eucalyptus-loaded oleogels exhibited good antibacterial activity against E. coli. The FTIR spectra of moringa-based oleogels in the range between 3226-3422 cm-1 indicate the presence of hydrogen bonding in oleogels.

Conclusion:The antioxidant potential of allantoin and eucalyptus-containing oleogel was maximized, and an IC50 value of 0.9719 µM was found. Maximum release of allantoin from oleogel was observed in the first hour.

About the authors

Nazia Yaqoob

Green Chemistry Lab, Department of Chemistry, Government College Women University Faisalababd

Author for correspondence.
Email: info@benthamscience.net

Fazeelat Imtiaz

Green Chemistry Lab, Department of Chemistry, Government College Women University Faisalababd

Email: info@benthamscience.net

Nusrat Shafiq

Synthetic and Natural Products drug discovery Lab., Department of Chemistry, Government College Women University Faisalabad

Author for correspondence.
Email: info@benthamscience.net

Saima Rehman

Department of Chemistry, Government College Women University Faisalabad

Email: info@benthamscience.net

Huma Munir

Green Chemistry Lab, Department of Chemistry, Government College Women University Faisalababd

Email: info@benthamscience.net

Mohammed Bourhia

Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University

Author for correspondence.
Email: info@benthamscience.net

Khalid Almaary

Department of Botany and Microbiology, College of Science,, King Saud University

Email: info@benthamscience.net

Hiba-Allah Nafidi

Department of Food Science, Faculty of Agricultural and Food Sciences, Laval University

Email: info@benthamscience.net

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