Amino Acids Profile in Children with Acute Brucellosis


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Background:Many new cases of brucella infections are seen in Turkey every year, especially in March, April, and May, due to the consumption of local unpasteurized cheese. Amino acids profiles have not been studied in brucellosis so far so far.

Aim:The amino acid profiles may be affected by infectious diseases. Our study aims to evaluate the plasma amino acid profile in the progression of acute brucellosis.

Methods:Plasma amino acid profile was performed by an 8045 LC-MS / MS device (Shimadzu 8045, Japan) using JASEM amino acid kit.

Results:Analysis of 45 amino acid profiles was made and results profiles showed significant differences in concentrations and types of amino acids in brucella patients. We observed a significant difference in terms of alanine, arginine, aspartic acid, glutamine, glutamic acid, glycine, isoleucine, ornithine, phenylalanine, proline, tyrosine, valine, alpha-aminoadipic acid, alpha-amino-pimelic ac-id, argininosuccinic acid, gamma-aminobutyric acid, thiaproline, 1-methylhistidine, 3-methylhisti- dine, hydroxylysine, hydroxyproline, cystine, serotonin, ethanolamine, and taurine (p-valup < 0.05 for each). No significant differences were determined regarding asparagine, citrulline, histidine, leucine, alloisoleucine, lysine, methionine, serine, threonine, tryptophan, anserine, alpha aminobu-tyric acid, beta aminoisobutyric acid, beta-alanine, cystathionine, histamine, and 5-oh-trp (p-value > 0.05 for all).

Conclusion:Patients with brucellosis have a specific profile of amino acids which may reflect sequelae of pathological and metabolic biochemical changes in the disease process due to the growth of Brucella spp. in the human body leading to an imbalance of amino acid levels.

Sobre autores

Ahmet Guzelcicek

Department of Pediatrics, Harran University, Medical School

Email: info@benthamscience.net

Nihayet Bayraktar

Department of Medical Biochemistry, Harran University, Medical School

Email: info@benthamscience.net

Mehmet Bayraktar

Department of Medical Microbiology, Harran University, Medical School

Autor responsável pela correspondência
Email: info@benthamscience.net

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