Amino Acids Profile in Children with Acute Brucellosis


Дәйексөз келтіру

Толық мәтін

Аннотация

Background:Many new cases of brucella infections are seen in Turkey every year, especially in March, April, and May, due to the consumption of local unpasteurized cheese. Amino acids profiles have not been studied in brucellosis so far so far.

Aim:The amino acid profiles may be affected by infectious diseases. Our study aims to evaluate the plasma amino acid profile in the progression of acute brucellosis.

Methods:Plasma amino acid profile was performed by an 8045 LC-MS / MS device (Shimadzu 8045, Japan) using JASEM amino acid kit.

Results:Analysis of 45 amino acid profiles was made and results profiles showed significant differences in concentrations and types of amino acids in brucella patients. We observed a significant difference in terms of alanine, arginine, aspartic acid, glutamine, glutamic acid, glycine, isoleucine, ornithine, phenylalanine, proline, tyrosine, valine, alpha-aminoadipic acid, alpha-amino-pimelic ac-id, argininosuccinic acid, gamma-aminobutyric acid, thiaproline, 1-methylhistidine, 3-methylhisti- dine, hydroxylysine, hydroxyproline, cystine, serotonin, ethanolamine, and taurine (p-valup < 0.05 for each). No significant differences were determined regarding asparagine, citrulline, histidine, leucine, alloisoleucine, lysine, methionine, serine, threonine, tryptophan, anserine, alpha aminobu-tyric acid, beta aminoisobutyric acid, beta-alanine, cystathionine, histamine, and 5-oh-trp (p-value > 0.05 for all).

Conclusion:Patients with brucellosis have a specific profile of amino acids which may reflect sequelae of pathological and metabolic biochemical changes in the disease process due to the growth of Brucella spp. in the human body leading to an imbalance of amino acid levels.

Авторлар туралы

Ahmet Guzelcicek

Department of Pediatrics, Harran University, Medical School

Email: info@benthamscience.net

Nihayet Bayraktar

Department of Medical Biochemistry, Harran University, Medical School

Email: info@benthamscience.net

Mehmet Bayraktar

Department of Medical Microbiology, Harran University, Medical School

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Әдебиет тізімі

  1. Dadar M, Shahali Y, Wareth G. Molecular diagnosis of acute and chronic brucellosis in humans. In: Microbial Technology for the Welfare of Society. Germany: Springer 2019; pp. 223-45.
  2. Díaz R, Moriyón I. Laboratory techniques in the diagnosis of human brucellosis. In: Brucellosis: Clinical and Laboratory Aspects. Florida, USA: CRC Press 2020; pp. 73-83. doi: 10.1201/9781003068518-8
  3. Saddique A, Ali S, Akhter S, et al. Acute febrile illness caused by Brucella abortus infection in humans in Pakistan. Int J Environ Res Public Health 2019; 16(21): 4071. doi: 10.3390/ijerph16214071 PMID: 31652718
  4. Djangwani J, Ooko Abong’ G, Gicuku Njue L, Kaindi DWM. Brucellosis: Prevalence with reference to East African community countries – A rapid review. Vet Med Sci 2021; 7(3): 851-67. doi: 10.1002/vms3.425 PMID: 33421354
  5. Mol JPS, Guedes ACB, Eckstein C, et al. Diagnosis of canine brucellosis: Comparison of various serologic tests and PCR. J Vet Diagn Invest 2020; 32(1): 77-86. doi: 10.1177/1040638719891083 PMID: 31752635
  6. Ren J, Peng Q. A brief review of diagnosis of small ruminants brucellosis. Curr Med Chem 2021; 28-4576(22): 4569-76. doi: 10.2174/0929867328666201231121226
  7. Tian M, Song M, Yin Y, et al. Characterization of the main immunogenic proteins in Brucella infection for their application in diagnosis of brucellosis. Comp Immunol Microbiol Infect Dis 2020; 70: 101462. doi: 10.1016/j.cimid.2020.101462 PMID: 32143107
  8. Yagupsky P, Morata P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev 2019; 33(1): e00073-19. doi: 10.1128/CMR.00073-19
  9. Nie C, He T, Zhang W, Zhang G, Ma X. Branched chain amino acids: Beyond nutrition metabolism. Int J Mol Sci 2018; 19(4): 954. doi: 10.3390/ijms19040954 PMID: 29570613
  10. Stabler SP. Alterations in sulfur amino acids as biomarkers of disease. J Nutr 2020; 150 (Suppl. 1): 2532S-7S. doi: 10.1093/jn/nxaa118 PMID: 33000156
  11. Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: A systematic review and meta-analysis. PLoS Negl Trop Dis 2012; 6(12): e1929. doi: 10.1371/journal.pntd.0001929 PMID: 23236528
  12. Adetunji SA, Ramirez G, Foster MJ, Arenas-Gamboa AM. A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. PLoS Negl Trop Dis 2019; 13(1): e0007112. doi: 10.1371/journal.pntd.0007112 PMID: 30657765
  13. Artuk C. GUL H. Complications and treatment of brucellosis: 11-year results. Acta Med Mediter 2019; 35: 1131. doi: 10.19193/0393-6384_2019_3_201
  14. Sen P, Demirdal T, Nemli SA. Predictive value of inflammation markers in brucellosis. Arch Iran Med 2019; 22(11): 640-5. PMID: 31823629
  15. Zheng R, Xie S, Lu X, et al. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. BioMed Res Int 2018; 2018: 5712920. doi: 10.1155/2018/5712920 PMID: 29850535
  16. Figura M. Kuśmierska K, Bucior E, et al. Serum amino acid profile in patients with Parkinson’s disease. PLoS One 2018; 13(1): e0191670. doi: 10.1371/journal.pone.0191670 PMID: 29377959
  17. Rahimi N, Razi F, Nasli-Esfahani E, Qorbani M, Shirzad N, Larijani B. Amino acid profiling in the gestational diabetes mellitus. J Diabetes Metab Disord 2017; 16(1): 13. doi: 10.1186/s40200-016-0283-1 PMID: 28367428
  18. Wang L, Liu S, Yang W, et al. Plasma amino acid profile in patients with aortic dissection. Sci Rep 2017; 7(1): 40146. doi: 10.1038/srep40146 PMID: 28071727
  19. Ablin J, Mevorach D, Eliakim R. Brucellosis and the gastrointestinal tract. The odd couple. J Clin Gastroenterol 1997; 24(1): 25-9. doi: 10.1097/00004836-199701000-00005 PMID: 9013346
  20. Aziz S, Al-Anazi A, Al-Aska A. A review of gastrointestinal manifestations of Brucellosis. Saudi J Gastroenterol 2005; 11(1): 20-7. doi: 10.4103/1319-3767.33333 PMID: 19861843
  21. Ahlman B, Ljungqvist O, Persson B, Bindslev L, Wernerman J. Intestinal amino acid content in critically ill patients. JPEN J Parenter Enteral Nutr 1995; 19(4): 272-8. doi: 10.1177/0148607195019004272 PMID: 8523625
  22. Woo HI, Chun MR, Yang JS, et al. Plasma amino acid profiling in major depressive disorder treated with selective serotonin reuptake inhibitors. CNS Neurosci Ther 2015; 21(5): 417-24. doi: 10.1111/cns.12372 PMID: 25611566
  23. Dileep-Satya K, Attri SV, Sharawat IK, et al. Plasma and urinary amino acid profile in children with infantile tremor syndrome. J Trop Pediatr 2021; 67(3): fmab063. doi: 10.1093/tropej/fmab063
  24. Tinkov AA, Skalnaya MG, Skalny AV. Serum trace element and amino acid profile in children with cerebral palsy. J Trace Elem Med Biol 2021; 64: 126685. doi: 10.1016/j.jtemb.2020.126685 PMID: 33249374
  25. Reinehr T, Wolters B, Knop C, et al. Changes in the serum metabolite profile in obese children with weight loss. Eur J Nutr 2015; 54(2): 173-81. doi: 10.1007/s00394-014-0698-8 PMID: 24740590

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