Email this article Bioactive Vitamins and Epigenetic Modifications in Diabetes: A Perspective
- Authors: Găman M.1,2, Cozma E.3,4, Srichawla B.5, Cozma M.1,6, Kord Varkaneh H.7,8, Chen Y.9, Găman A.10,11, Diaconu C.1,12
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Affiliations:
- Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest 050474, Romania
- Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 258 Fundeni Road, Bucharest 022328, Romania
- Department of Dermatology, Elias Clinical Emergency Hospital, 15 Marasti Boulevard, Bucharest 011461, Romania
- Doctoral School, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200349, Romania
- Department of Neurology, University of Massachusetts Chan Medical School. 55 Lake Ave N Worcester MA 01655, United States of America
- Department of Gastroenterology, Colentina Clinical Hospital, 19-21 Stefan cel Mare Road, Bucharest 020125, Romania
- Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Department of Nutrition and Food Hygiene, Nutritional Health Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
- Department of Basic Medical Sciences, Medical College of Taizhou University, Taizhou, Zhejiang, 318000, China
- Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Clinic of Hematology, Filantropia City Hospital, 200143 Craiova, Romania
- Internal Medicine Clinic, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania
- Issue: Vol 20, No 1 (2024)
- Section: Medicine
- URL: https://gynecology.orscience.ru/1573-3998/article/view/642949
- DOI: https://doi.org/10.2174/1573399819666230330124035
- ID: 642949
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Abstract
Diabetes is a complex metabolic disease that has been associated with epigenetic changes. External factors such as dietary patterns can induce an imbalance in the pools of micronutrients and macronutrients in the body. Consequently, bioactive vitamins may influence epigenetic mechanisms via several pathways: involvement in the control of gene expression, and in protein synthesis, by acting as coenzymes and co-factors in the metabolism of methyl groups or methylation of DNA and histones. Herein, we present a perspective on the relevance of bioactive vitamins in the epigenetic modifications that occur in diabetes.
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About the authors
Mihnea-Alexandru Găman
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest050474, Romania; Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 258 Fundeni
Road, Bucharest 022328, Romania
Author for correspondence.
Email: info@benthamscience.net
Elena-Codruța Cozma
Department of Dermatology, Elias Clinical Emergency Hospital, 15 MarastiBoulevard, Bucharest 011461, Romania; Doctoral School, University of Medicine and Pharmacy of Craiova, 2 Petru
Rares Street, Craiova 200349, Romania
Email: info@benthamscience.net
Bahadar Srichawla
Department of Neurology, University of Massachusetts Chan Medical School.55 Lake Ave N Worcester MA 01655, United States of America
Email: info@benthamscience.net
Matei-Alexandru Cozma
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest050474, Romania; Department of Gastroenterology, Colentina Clinical
Hospital, 19-21 Stefan cel Mare Road, Bucharest 020125, Romania
Email: info@benthamscience.net
Hamed Kord Varkaneh
Department of Clinical Nutrition and Dietetics,Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti
University of Medical Sciences, Tehran, Iran; Department of Nutrition and Food Hygiene, Nutritional Health Research
Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Email: info@benthamscience.net
Yongfeng Chen
Department of Basic MedicalSciences, Medical College of Taizhou University, Taizhou, Zhejiang, 318000, China
Email: info@benthamscience.net
Amelia Găman
Department of Pathophysiology,University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania; Clinic of Hematology, Filantropia City
Hospital, 200143 Craiova, Romania
Author for correspondence.
Email: info@benthamscience.net
Camelia Diaconu
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest050474, Romania; Internal Medicine Clinic, Clinical Emergency Hospital of Bucharest, 105402
Bucharest, Romania
Email: info@benthamscience.net
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