STNMDA: A Novel Model for Predicting Potential Microbe-Drug Associations with Structure-Aware Transformer


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Introduction:Microbes are intimately involved in the physiological and pathological processes of numerous diseases. There is a critical need for new drugs to combat microbe-induced diseases in clinical settings. Predicting potential microbe-drug associations is, therefore, essential for both disease treatment and novel drug discovery. However, it is costly and time-consuming to verify these relationships through traditional wet lab approaches.

Methods:We proposed an efficient computational model, STNMDA, that integrated a StructureAware Transformer (SAT) with a Deep Neural Network (DNN) classifier to infer latent microbedrug associations. The STNMDA began with a "random walk with a restart" approach to construct a heterogeneous network using Gaussian kernel similarity and functional similarity measures for microorganisms and drugs. This heterogeneous network was then fed into the SAT to extract attribute features and graph structures for each drug and microbe node. Finally, the DNN classifier calculated the probability of associations between microbes and drugs.

Results:Extensive experimental results showed that STNMDA surpassed existing state-of-the-art models in performance on the MDAD and aBiofilm databases. In addition, the feasibility of STNMDA in confirming associations between microbes and drugs was demonstrated through case validations.

Conclusion:Hence, STNMDA showed promise as a valuable tool for future prediction of microbedrug associations.

Sobre autores

Liu Fan

College of Computer Science and Technology, Hengyang Normal University

Email: info@benthamscience.net

Xiaoyu Yang

, Changsha University, Big Data Innovation and Entrepreneurship Education Center of Hunan Province

Email: info@benthamscience.net

Lei Wang

, Changsha University, Big Data Innovation and Entrepreneurship Education Center of Hunan Province

Autor responsável pela correspondência
Email: info@benthamscience.net

Xianyou Zhu

, College of Computer Science and Technology, Hengyang Normal University

Autor responsável pela correspondência
Email: info@benthamscience.net

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