Probiotics in obstetric practice: efficacy and safety

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The intestinal microbiota modulates immune programming and can prevent the realization of an allergic phenotype. For the formation of a normal microbiocenosis of the intestine, skin and oral cavity, a sufficient quantitative and qualitative bacterial colonization of the newborn is necessary during the transition from a «sterile» intrauterine environment to microbial colonization, resulting in the appearance of more than 1014 microorganisms. Low levels of bifidobacteria and early colonization of potentially pathogenic bacteria are associated with the development of severe allergic reactions. Prescribing probiotics containing Lactobacillus rhamnosus GG (LGG) at a concentration of 108–1010 CFU from 36 weeks of gestation and during the first 3–4 months of lactation is associated with a 21% reduction in the risk of allergic reactions in the child.

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About the authors

Juliia E. Dobrokhotova

Pirogov Russian National Research Medical University

ORCID iD: 0000-0001-5388-3669

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Ekaterina I. Borovkova

Pirogov Russian National Research Medical University

Author for correspondence.

Russian Federation, Moscow

D. Sci. (Med.), Prof.


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