Chronic endometritis in women with endometriosis-associated infertility

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Abstract


The article highlights modern ideas about the role of the endometrium in the genesis of reproductive failures. A crucial place of chronic endometritis in the structure of the endometrial infertility factor in endometriosis is noted. Given the frequent association of chronic endometritis and endometriosis, common features of these diseases have been identified. The characteristic of endometrial microbiota in infertility, chronic endometritis and endometriosis is given. An extremely important area of scientific research is precisely the interaction between the microbiota of the endometrium and its immunity, and not just the confirmation of the presence of microorganisms in the endometrium. The modern aspects of the etiology and pathogenesis of chronic endometritis and endometriosis are described. The main pathogenetic determinants of chronic endometritis are the failure of adaptation mechanisms to the constant effects of microbes and, as a consequence, the decrease and inferiority of the immune response and the development of autoimmune reactions. The modern paradigm for the development and progression of endometriosis involves the presence of bacterial contamination of the endometrium and the abdominal cavity, which in turn becomes a trigger for genetically-epigenetic modifications of cells, launching different cascades that underlie reproductive function disorders. The pathogenetically significant relationship between chronic endometritis and endometriosis is highlighted. It was revealed that chronic endometritis can be both a cause and a consequence of endometriosis. Disorders of the endometrial receptivity in chronic endometritis associated with endometriosis, their importance in the implementation of endometrial infertility are described. The important role of the microbiome in the formation of reproductive disorders is noted.


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About the authors

Mekan R. Orazov

Peoples’ Friendship University of Russia

Author for correspondence.
Email: omekan@mail.ru
ORCID iD: 0000-0002-5342-8129

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Victor E. Radzinsky

People’s Friendship University of Russia

Email: radzinsky@mail.ru
ORCID iD: 0000-0003-4956-0466

Russian Federation, Moscow

Corr. Memb. RAS, D. Sci. (Med.), Prof.

Snezhana V. Volkova

People’s Friendship University of Russia

Email: dr.slupus@yandex.ru
ORCID iD: 0000-0003-2198-7927

Russian Federation, Moscow

Graduate Student

Marina B. Khamoshina

Moscow

Email: khamoshina@mail.ru
ORCID iD: 0000-0003-1940-4534

Russian Federation, People’s Friendship University of Russia

D. Sci. (Med.), Prof.

Ludmila M. Mikhaleva

Research Institute of Human Morphology

Email: mikhalevam@yandex.ru
ORCID iD: 0000-0003-2052-914X

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Marianna Z. Abitova

People’s Friendship University of Russia

Email: abitovamarianna@yandex.ru
ORCID iD: 0000-0002-2684-5322

Russian Federation, Moscow

Graduate Student

Victoria B. Shustova

MedInService – Center for Reproduction and Genetics “Nova Clinic” (“MedInService”)

Email: shustova.vik@yandex.ru
ORCID iD: 0000-0003-4397-0042

Russian Federation, Moscow

obstetrician-gynecologist, reproductologist

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