Reccurence of endometrioid ovarian cysts and possible ways to its reduce

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Abstract


Aim. Comparative evaluation of the effectiveness of various types of hormone therapy for the prevention of relapses of endometrioid cysts (EC), based on clinical observation and data analysis.

Materials and methods. Retrospective analysis of 122 patients (the average age 31.7±6.12 years) with laparoscopically confirmed endometriosis. Patients were divided into groups, according to the treatment options – aGnRH (n=11), COCs (n=13), dienogest (Visanne®) (n=56). A comparison group included 42 patients who did not receive hormone therapy. There were evaluated the number of reccurence in the group without therapy and in groups with different options for hormonal therapy.

Results. Among patients treated with hormone therapy, the recurrence rate of EC was 3.75%, among those who have not received therapy – 38.1%. Of these, 31.1% of patients had recurrence rate of EC during the first year, 37.8% during 3 years, and 31.1% after 3 years. After suppressive therapy was discontinued, the relapse rate in the aGnRH group was 63.6%, COC – 50%, dienogest – 24%.

Conclusions. In addition to evaluating the ovarian reserve before and after surgical treatment, management tactics for patients with EC should include the long-term administration of dienogest as an anti-relapse therapy.


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About the authors

Dmitrii V. Gusev

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Author for correspondence.
Email: doctor.dgusev@gmail.com
ORCID iD: 0000-0001-7661-3389

Russian Federation, Moscow

Research Officer

Viktoriia Yu. Prilutskaya

Sechenov First Moscow State Medical University (Sechenov University)

Email: anturiumvika@mail.ru
ORCID iD: 0000-0003-3319-182X

Russian Federation, Moscow

Graduate Student

Galina E. Chernukha

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: c-galina1@yandex.ru
ORCID iD: 0000-0002-9065-5689

Russian Federation, Moscow

D. Sci. (Med.), Prof.

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