Use of a drug containing ornidazole-neomycin–prednisolone–econazole for the empirical treatment of vaginal infections

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Abstract


Relevance. Empirical treatment of vaginitis is indicated due to its polymicrobial etiology and limited microbiological analysis. The aim of the study was to study the combination of ornidazole–neomycin–prednisolone–econazole (ONPE, Elzhina®) as a first-line drug for local treatment of patients with various forms of non-specific vaginitis.

Materials and methods. The study included 55 non-pregnant women aged 18 to 50 years (38±1.5 years) who had clinical and laboratory signs of acute vaginitis.

Results. All patients at the initial treatment complained of pathological discharge, 47 (85.5%) noted itching, burning, pain in the genital area of various degrees of severity, 17 (30.9%) – discomfort when urinating, 9 (16.4%) – unpleasant smell, 8 (14.5%) – dyspareunia, 4 (2.2%)– complained of sensations of a foreign body in the vagina. The clinical and laboratory effectiveness of treatment was 89.1% (49). In 6 (10.9%) patients, clinical improvement was noted, with the remaining laboratory signs of aerobic vaginitis.

Conclusion. The new combination of ornidazole–neomycin–prednisolone–econazole (ONPE, Elzhina® ) has a good efficacy and safety profile and can be used to initiate empirical treatment of non-specific inflammatory diseases of the lower genital tract.


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About the authors

Valerii G. Volkov

Author for correspondence.
Email: valvol@yandex.ru
ORCID iD: 0000-0002-7274-3837

Russian Federation

D. Sci. (Med.), Tula State University

Tatyana V. Zakharova

Email: valvol@yandex.ru
ORCID iD: 0000-0001-7716-0983

Russian Federation

Cand. Sci. (Med.), Lazarev City Clinical Hospital №2

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